View RSS feed

Publications

Showing posts 111 to 120 of 173 total

Mécanique des fluides

Out-of-Equilibrium Measurements of Kinetic Constants on a Biosensor

Conventional measurements of kinetic constants currently in use are performed at equilibrium and may require large volumes, especially at low association rate constant k on. If the measurements are made out of equilibrium, the values obtained may be…

Donatien Mottin, Florence Razan, Claude Nogues, Marie-Caroline Jullien

Analytical Chemistry -

Biochimie

Endogenous Bos taurus RECQL is predominantly monomeric and more active than oligomers

There is broad consensus that RecQ family helicase is a high-order oligomer that dissociates into a dimer upon ATP binding. This conclusion is based mainly on studies of highly purified recombinant proteins, and the oligomeric states of RecQ…

Na-Nv Liu, Ze-Yu Song, Hai-Lei Guo, Hu Yin, Wei-Fei Chen, Yang-Xue Dai, Ben-Ge Xin, Xia Ai, Lei Ji, Qing-Man Wang, Xi-Miao Hou, Shuo-Xing Dou, Stephane Rety, Xu-Guang Xi

Cell Reports -

Biochimie, Biologie Moléculaire

The allosteric activation mechanism of a phospholipase A2-like toxin from Bothrops jararacussu venom: a dynamic description

Abstract The activation process of phospholipase A 2 -like (PLA 2 -like) toxins is a key step in their molecular mechanism, which involves oligomeric changes leading to the exposure of specific sites. Few studies have focused on the characterization…

Antoniel Gomes, Fabio Cardoso, Maximilia Souza, Cristiano Oliveira, David Perahia, Angelo Magro, Marcos Fontes

Scientific Reports -

Chimie

Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1 H -pyrazole-5-carboxylate as an HIV-1 replication inhibitor

Inspired by the antiviral activity of known pyrazole-based HIV inhibitors, we screened our in-house library of pyrazole-based compounds to evaluate their in cellulo activity against HIV-1 replication. Two hits with very similar structures appeared…

Jeanne Fichez, Cathia Soulie, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier-Pelletier, Anne-Geneviève Marcelin, Vincent Calvez, Patricia Busca

RSC Medicinal Chemistry -

Bio-Informatique, Biologie Systémique

A New Strategy for Atomic Flexible Fitting in Cryo-EM Maps by Molecular Dynamics with Excited Normal Modes (MDeNM-EMfit)

Previous studies demonstrated the efficiency of the Molecular Dynamics with excited Normal Modes (MDeNM) method on the characterization of large structural changes at a low computational cost. We present here MDeNM-EMfit, an extension of the…

Mauricio G S Costa, Charline Fagnen, Catherine Vénien-Bryan, David Perahia

Journal of Chemical Information and Modeling -

Biophysique

Gold nanorods-based oligonucleotides carrier quantitative characterisation

Gold nanorods (GNRs) are attracting a lot of attention due to their extraordinary optical properties, and potential use for medical applications. The issue of the attachment of double stranded oligonucleotides onto GNR surfaces is crucial for the…

Henryk Laszewski, Bruno Palpant, Malcolm Buckle, Claude Nogues

2020 International Conference Laser Optics (ICLO) -

Biotechnologies

Suitability of the Lebanese “Ace Spur” Apple Variety for Cider Production Using Hanseniaspora sp. Yeast

In the present research work, the physicochemical and fermentative properties of the “Ace spur” apple variety, obtained from a Lebanese farm, and the “Kermerrien” variety, obtained from a French cider industry, were investigated. The pomological…

Marina Al Daccache, Mohamed Koubaa, Richard G. Maroun, Dominique Salameh, Nicolas Louka, Eugene Vorobiev

Fermentation -