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Showing posts 131 to 140 of 170 total

Biotechnologies

Suitability of the Lebanese “Ace Spur” Apple Variety for Cider Production Using Hanseniaspora sp. Yeast

In the present research work, the physicochemical and fermentative properties of the “Ace spur” apple variety, obtained from a Lebanese farm, and the “Kermerrien” variety, obtained from a French cider industry, were investigated. The pomological…

Marina Al Daccache, Mohamed Koubaa, Richard G. Maroun, Dominique Salameh, Nicolas Louka, Eugene Vorobiev

Fermentation -

Biologie cellulaire

Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial

Objective: To assess masitinib in the treatment of ALS. Methods: Double-blind study, randomly assigning 394 patients (1:1:1) to receive riluzole (100 mg/d) plus placebo or masitinib at 4.5 or 3.0 mg/kg/d. Following a blinded transition from phase 2…

Jesus Mora, Angela Genge, Adriano Chiò, Conrado Estol, Delia Chaverri, Maria Hernández, Saúl Marín, Javier Mascias, Gabriel Rodríguez, Monica Povedano, Andrés Paipa, Raúl Dominguez, Josep Gámez, Maria Salvado, Christian Lunetta, Carlos Ballario, Nilo Riva, Jessica Mandrioli, Alain Moussy, Jean-Pierre Kinet, Christian Auclair, Patrice Dubreuil, Vincent Arnold, Colin Mansfield, Olivier Hermine

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration -

Biophysique

Harnessing intrinsic fluorescence for typing of secondary structures of DNA

High-throughput investigation of structural diversity of nucleic acids is hampered by the lack of suitable label-free methods, combining fast and cheap experimental workflow with high information content. Here, we explore the use of intrinsic…

Michela Zuffo, Aurélie Gandolfini, Brahim Heddi, Anton Granzhan

Nucleic Acids Research -

Génomique, Transcriptomique et Protéomique

Early fate of exogenous promoters in E. coli

Gene gain by horizontal gene transfer is a major pathway of genome innovation in bacteria. The current view posits that acquired genes initially need to be silenced and that a bacterial chromatin protein, H-NS, plays a role in this silencing…

Malikmohamed Yousuf, Ilaria Iuliani, Reshma T Veetil, Aswin Sai Narain Seshasayee, Bianca Sclavi, Marco Cosentino Lagomarsino

Nucleic Acids Research -

Sciences du Vivant

Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP

The ter region of the bacterial chromosome, where replication terminates, is the last to be segregated before cell division in Escherichia coli. Delayed segregation is controlled by the MatP protein, which binds to specific sites (matS) within ter,…

Estelle Crozat, Catherine Tardin, Maya Salhi, Philippe Rousseau, Armand Lablaine, Tommaso Bertoni, David Holcman, Bianca Sclavi, Pietro Cicuta, François Cornet

Nature Communications -

Sciences du Vivant

Human RPA activates BLM’s bidirectional DNA unwinding from a nick

BLM is a multifunctional helicase that plays critical roles in maintaining genome stability. It processes distinct DNA substrates, but not nicked DNA, during many steps in DNA replication and repair. However, how BLM prepares itself for diverse…

Zhenheng Qin, Lulu Bi, Xi-Miao Hou, Siqi Zhang, Xia Zhang, Ying Lu, Ming Li, Mauro Modesti, Xu-Guang Xi, Bo Sun

eLife -

Polymères

Fluorescent Copolymers for Bacterial Bioimaging and Viability Detection

Novel fluorescent labels with high photostability and high biocompatibility are required for microbiological imaging and detection. Here, we present a green fluorescent polymer chain (GFPC), designed to be nontoxic and water-soluble, for multicolor…

Yang Si, Chloé Grazon, Gilles Clavier, Jutta Rieger, Yayang Tian, Jean-Frédéric Audibert, Bianca Sclavi, Rachel Méallet-Renault

ACS Sensors -