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Showing posts 121 to 130 of 173 total

Alimentation et Nutrition

Selective ultrasound‐assisted aqueous extraction of polyphenols from pomegranate peels and seeds

In this study, the optimization of ultrasound‐assisted aqueous extraction of polyphenols from pomegranate peels and seeds was conducted. A 10‐min sonication (tu ) pre‐treatment (≈60 W) accelerated the extraction kinetics and intensified the…

Hiba Rajha, Mohamed Koubaa, Nadia Boussetta, Richard G. Maroun, Nicolas Louka, Nikolaï Lebovka, Eugene Vorobiev

Journal of Food Processing and Preservation -

Biochimie, Biologie Moléculaire

Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States

HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the…

Assia Mouhand, Marco Pasi, Marjorie Catala, Loussiné Zargarian, Anissa Belfetmi, Pierre Barraud, Olivier Mauffret, Carine Tisné

Viruses -

Santé publique et épidémiologie

A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome

Bahia Bekhouche, Aurore Tourville, Yamini Ravichandran, Rachida Tacine, Laurence Abrami, Michaël Dussiot, Andrea Khau-Dancasius, Olivia Boccara, Meriem Khirat, Marianne Mangeney, Florent Dingli, Damarys Loew, Batiste Boëda, Pénélope Jordan, Thierry Jo Molina, Nathalia Bellon, Sylvie Fraitag, Smaïl Hadj-Rabia, Stephane Blanche, Anne Puel, Sandrine Etienne-Manneville, F Gisou van Der Goot, Jacqueline Cherfils, Olivier Hermine, Jean-Laurent Casanova, Christine Bodemer, Asma Smahi, Jérôme Delon

Journal of Allergy and Clinical Immunology -

Sciences de l'environnement

Protein Kinase D1 (PKD1) Is a New Functional Non-Genomic Target of Bisphenol A in Breast Cancer Cells

Exposure to bisphenol A (BPA), one of the most widespread endocrine disruptors present in our environment, has been associated with the recent increased prevalence and severity of several diseases such as diabetes, obesity, autism, reproductive and…

Messaouda Merzoug-Larabi, Ilige Youssef, Ai Thu Bui, Christine Legay, Sophia Loiodice, Sophie Lognon, Sylvie Babajko, Jean-Marc Ricort

Frontiers in Pharmacology -

Pharmacologie

A Decrease in Transcription Capacity Limits Growth Rate upon Translation Inhibition

In bacterial cells, inhibition of ribosomes by sublethal concentrations of antibiotics leads to a decrease in the growth rate despite an increase in ribosome content. The limitation of ribosomal activity results in an increase in the level of…

Qing Zhang, Elisa Brambilla, Rui Li, Hualin Shi, Marco Cosentino Lagomarsino, Bianca Sclavi

mSystems -

Sciences du Vivant

A Toolbox for Site-Specific Labeling of RecQ Helicase With a Single Fluorophore Used in the Single-Molecule Assay

Fluorescently labeled proteins can improve the detection sensitivity and have been widely used in a variety of biological measurements. In single-molecule assays, site-specific labeling of proteins enables the visualization of molecular interactions…

Fang-Yuan Teng, Zong-Zhe Jiang, Ling-Yun Huang, Man Guo, Feng Chen, Xi-Miao Hou, Xu-Guang Xi, Yong Xu

Frontiers in Molecular Biosciences -

Sciences du Vivant

PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration

Corpus callosum agenesis (CCA) is a brain malformation associated with a wide clinical spectrum including intellectual disability (ID) and an etiopathological complexity. We identified a novel missense G424R mutation in the X-linked p21-activated…

Kévin Duarte, Solveig Heide, Sandrine Poea-Guyon, Veronique Rousseau, Christel Depienne, Agnès Rastetter, Caroline Nava, Tania Attié-Bitach, Ferechté Razavi, Jelena Martinovic, Marie Laure Moutard, Jacqueline Cherfils, Cyril Mignot, Delphine Héron, Jean-Vianney Barnier

Neurobiology of Disease -

Biochimie, Biologie Moléculaire

The N-terminal of NBPF15 causes multiple types of aggregates and mediates phase transition

The neuroblastoma breakpoint family (NBPF) consists of 24 members that play an important role in neuroblastoma and other cancers. NBPF is an evolutionarily recent gene family that encodes several repeats of Olduvai domain and an abundant N-terminal…

Han Wu, Liu-Tao Zhai, Xue-Xue Guo, Stéphane Réty, Xu-Guang Xi

Biochemical Journal -