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Showing posts 141 to 150 of 173 total

Agrégats Moléculaires et Atomiques

New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies

Inward rectifier potassium (Kir) channels play diverse and important roles in shaping action potentials in biological membranes. An increasing number of diseases are now known to be directly associated with abnormal Kir function. However, the gating…

Charline Fagnen, Ludovic Bannwarth, Iman Oubella, Eric Forest, Rita de Zorzi, Aline de Araujo, Yasmina Mhoumadi, Saïd Bendahhou, David Perahia, Catherine Vénien-Bryan

Scientific Reports -

Alimentation et Nutrition

Selective ultrasound‐assisted aqueous extraction of polyphenols from pomegranate peels and seeds

In this study, the optimization of ultrasound‐assisted aqueous extraction of polyphenols from pomegranate peels and seeds was conducted. A 10‐min sonication (tu ) pre‐treatment (≈60 W) accelerated the extraction kinetics and intensified the…

Hiba Rajha, Mohamed Koubaa, Nadia Boussetta, Richard G. Maroun, Nicolas Louka, Nikolaï Lebovka, Eugene Vorobiev

Journal of Food Processing and Preservation -

Biochimie, Biologie Moléculaire

Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States

HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the…

Assia Mouhand, Marco Pasi, Marjorie Catala, Loussiné Zargarian, Anissa Belfetmi, Pierre Barraud, Olivier Mauffret, Carine Tisné

Viruses -

Santé publique et épidémiologie

A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome

Bahia Bekhouche, Aurore Tourville, Yamini Ravichandran, Rachida Tacine, Laurence Abrami, Michaël Dussiot, Andrea Khau-Dancasius, Olivia Boccara, Meriem Khirat, Marianne Mangeney, Florent Dingli, Damarys Loew, Batiste Boëda, Pénélope Jordan, Thierry Jo Molina, Nathalia Bellon, Sylvie Fraitag, Smaïl Hadj-Rabia, Stephane Blanche, Anne Puel, Sandrine Etienne-Manneville, F Gisou van Der Goot, Jacqueline Cherfils, Olivier Hermine, Jean-Laurent Casanova, Christine Bodemer, Asma Smahi, Jérôme Delon

Journal of Allergy and Clinical Immunology -

Sciences de l'environnement

Protein Kinase D1 (PKD1) Is a New Functional Non-Genomic Target of Bisphenol A in Breast Cancer Cells

Exposure to bisphenol A (BPA), one of the most widespread endocrine disruptors present in our environment, has been associated with the recent increased prevalence and severity of several diseases such as diabetes, obesity, autism, reproductive and…

Messaouda Merzoug-Larabi, Ilige Youssef, Ai Thu Bui, Christine Legay, Sophia Loiodice, Sophie Lognon, Sylvie Babajko, Jean-Marc Ricort

Frontiers in Pharmacology -

Pharmacologie

A Decrease in Transcription Capacity Limits Growth Rate upon Translation Inhibition

In bacterial cells, inhibition of ribosomes by sublethal concentrations of antibiotics leads to a decrease in the growth rate despite an increase in ribosome content. The limitation of ribosomal activity results in an increase in the level of…

Qing Zhang, Elisa Brambilla, Rui Li, Hualin Shi, Marco Cosentino Lagomarsino, Bianca Sclavi

mSystems -

Biochimie, Biologie Moléculaire

Slow motions in A·T rich DNA sequence

In free B-DNA, slow (microsecond-to-millisecond) motions that involve equilibrium between Watson-Crick (WC) and Hoogsteen (HG) base-pairing expand the DNA dynamic repertoire that could mediate DNA-protein assemblies. R 1ρ relaxation dispersion NMR…

A Ben Imeddourene, L Zargarian, M Buckle, B Hartmann, Olivier Mauffret

Scientific Reports -