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Showing posts 161 to 170 of 173 total

Chimie thérapeutique

Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains

G-quadruplexes (G4s), which are structures formed in guanine-rich regions of DNA, are involved in a variety of significant biological functions, and therefore “sequence-dependent” selective G4-stabilizing agents are required as tools to investigate…

Yue Ma, Keisuke Iida, Shogo Sasaki, Takatsugu Hirokawa, Brahim Heddi, Anh Tuân Phan, Kazuo Nagasawa

Molecules -

Sciences du Vivant

Variability of the HIV-1 3′ polypurine tract (3′PPT) region and implication in integrase inhibitor resistance

Abstract Background Integrase strand-transfer inhibitors (INSTIs) are efficient at impairing retroviral integration, which is a critical step in HIV-1 replication. To date, resistance to these compounds has been explained by mutations in the viral…

Isabelle Malet, Olivier Delelis, Thuy Nguyen, Valentin Leducq, Besma Abdi, Laurence Morand-Joubert, Vincent Calvez, Anne-Geneviève Marcelin

Journal of Antimicrobial Chemotherapy -

Biologie structurale

MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus

In Myxococcus xanthus, directed movement is controlled by pole-to-pole oscillations of the small GTPase MglA and its GAP MglB. Direction reversals require that MglA is inactivated by MglB, yet paradoxically MglA and MglB are located at opposite…

Christian Galicia, Sebastien Lhospice, Paloma Fernández Varela, Stefano Trapani, Wenhua Zhang, Jorge Navaza, Julien Herrou, Tam Mignot, Jacqueline Cherfils

Nature Communications -

Biochimie, Biologie Moléculaire

Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis

During HIV-1 assembly and budding, Gag protein, in particular the C-terminal domain containing the nucleocapsid domain (NCd), p1 and p6, is the site of numerous interactions with viral and cellular factors. Most in vitro studies of Gag have used…

Assia Mouhand, Anissa Belfetmi, Marjorie Catala, Valéry Larue, Loussiné Zargarian, Franck Brachet, Robert J Gorelick, Carine van Heijenoort, Gilles Mirambeau, Pierre Barraud, Olivier Mauffret, Carine Tisné

Nucleic Acids Research -

Biochimie, Biologie Moléculaire

On the effect of alkaline pH and cofactor availability in the conformational and oligomeric state of Escherichia coli glutamate decarboxylase

Escherichia coli glutamate decarboxylase (EcGad) is a homohexameric pyridoxal 5′-phosphate (PLP)-dependent enzyme. It is the structural component of the major acid resistance system that protects E. coli from strong acid stress (pH

F. Giovannercole, C. Mérigoux, C. Zamparelli, D. Verzili, G. Grassini, M. Buckle, P. Vachette, D. de Biase

Protein Engineering, Design and Selection -

Biochimie, Biologie Moléculaire

Insights into the mechanisms of RNA secondary structure destabilization by the HIV-1 nucleocapsid protein

The mature HIV-1 nucleocapsid protein NCp7 (NC) plays a key role in reverse transcription facilitating the two obligatory strand transfers. Several properties contribute to its efficient chaperon activity: preferential binding to single-stranded…

Anissa Belfetmi, Loussiné Zargarian, Carine Tisné, Dona Sleiman, Nelly Morellet, Ewen Lescop, Ouerdia Maskri, Brigitte René, Yves Mély, Philippe Fossé, Olivier Mauffret

RNA -

Pharmacologie

Dual and Opposite Effects of hRAD51 Chemical Modulation on HIV-1 Integration.

The cellular DNA repair hRAD51 protein has been shown to restrict HIV-1 integration both in vitro and in vivo. To investigate its regulatory functions, we performed a pharmacological analysis of the retroviral integration modulation by hRAD51. We…

Sylvain Thierry, Mohamed Salah Benleulmi, Ludivine Sinzelle, Eloise Thierry, Christina Calmels, Stephane Chaignepain, Pierre Waffo-Teguo, Jean-Michel Merillon, Brian Budke, Jean-Max Pasquet, Simon Litvak, Angela Ciuffi, Patrick Sung, Philip Connell, Ilona Hauber, Joachim Hauber, Marie-Line Andreola, Olivier Delelis, Vincent Parissi

Journal of Chemical Biology -

Chimie

Impact of the Ku Complex on HIV-1 Expression and Latency

Ku, a cellular complex required for human cell survival and involved in double strand break DNA repair and multiple other cellular processes, may modulate retroviral multiplication, although the precise mechanism through which it acts is still…

Gwenola Manic, Ilio Vitale, Jean François Mouscadet, Philippe Dessen, Sylvain Thierry, Fanny Laurent, Uriel Hazan, Michelle Vincendeau, Christine Leib-Mösch, Olivier Delelis, Aurélie Maurin-Marlin, S. Bury-Moné

PLoS ONE -