Publié

Biochimie, Biologie Moléculaire

On the effect of alkaline pH and cofactor availability in the conformational and oligomeric state of Escherichia coli glutamate decarboxylase

Publié le - Protein Engineering, Design and Selection

Auteurs : F. Giovannercole, C. Mérigoux, C. Zamparelli, D. Verzili, G. Grassini, M. Buckle, P. Vachette, D. de Biase

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Escherichia coli glutamate decarboxylase (EcGad) is a homohexameric pyridoxal 5′-phosphate (PLP)-dependent enzyme. It is the structural component of the major acid resistance system that protects E. coli from strong acid stress (pH