Rho family small GTPases are essential for cytokinesis completion. RacGAP1, a dimeric multidomain protein with a lipid‐binding C1 domain and a GTPase‐activating protein (GAP) domain, is a major regulator in this process. However, despite many…
Importance Evidence regarding efficacy and safety of thrombectomy in acute ischemic stroke (AIS) due to medium or distal vessel occlusions (MDVOs) is lacking. Objective To evaluate the benefit of thrombectomy, in addition to medical treatment over…
Frédéric Clarençon, Fouzi Bala, Amandine Baptiste, Marco Pasi, Gaultier Marnat, Igor Sibon, Benjamin Gory, Sébastien Richard, Raoul Pop, Valérie Wolff, Cédric Fauché, Matthias Lamy, Vincent Costalat, Caroline Arquizan, Christine Rodriguez-Régent, Guillaume Turc, Christophe Cognard, Louis Fontaine, Federico Di Maria, Bertrand Lapergue, Nicolas Bricout, Hilde Henon, Titien Tuilier, Aymeric Wittwer, Pierre Louis Alexandre, Solène de Gaalon, Laurent Spelle, Christian Denier, Emmanuel Chabert, Anna Ferrier, Aymeric Rouchaud, Francisco Macian-Montoro, Sébastien Soize, Solène Moulin, William Boisseau, Candice Sabben, Charlotte Barbier, Marion Boulanger, Omer Faruk Eker, Tae-Hee Cho, Jean-Christophe Gentric, Serge Timsit, Marc-Antoine Labeyrie, Peggy Reiner, Fernando Pico, Isabelle Durand-Zaleski, Sonia Alamowitch, Agnès Dechartres, Rémy Beaujeux, Dan Mihoc, Monica Manisor, Véronique Quenardelle, Irène Pierre-Paul, Roxana Gheoca, Emmanuel Wiener, Ian Leonard-Lorant, Anca Hasiu, René Anxionnat, Anne-Laure Derelle, Liang Liao, François Zhu, Oana Harsan, Emmanuelle Schmitt, Sophie Planel, Lisa Humbertjean-Selton, Gioia Mione, Jean-Christophe Lacour, Marian Douarinou, Nabil Kassem, Emilien Micard, Bailiang Chen, Marcela Voicu, Marie Reitter, Madalina Brezeanu, Adriana Tabarna, Iona Podar, Pauline Bourst, Grégoire Barthel, Alexandre Voulot, Guillaume Thebault, Catherine Morais, Adrien Wang, Oguzhan Coskun, Silvia Pizzuto, Alessandro Sgreccia, David Weisenburger-Lile, Maia Tchikviladze, Constance Lesoil-Markowski, Victoria Vernier, Cédric Batot, Manon Escalere, Georges Rodesch, Arturo Consoli, Delphine Lopez, Lisa Neumann, Vittorio Civelli, Alexis Guédon, Agnès Aghetti, Stéphanie Guey, Tuan Huy Tran, Mikael Mazighi, Giulia Frasca-Polara, Hugues Chabriat, Eric Jouvent, Mathilde Aubertin, Emmanuel Houdart, Jean-Pierre Saint-Maurice, Francesco Arpaia, Matteo Fantoni, Olivier Naggara, Valérie Domigo, Wagih Ben Hassen, Clémence Liégeois, Antoine Dusonchet, Denis Trystram, Clothilde Isabel, Hugo Gortais, Nicolas Mélé, Catherine Oppenheim, David Calvet, Despina Messimeris, Armand Aymard, François Lun, Charbel Mounayer, Suzana Saleme, Simon Frachet, Alexandre Cosnard, Charlotte Rosso, Sara Leder, Flore Baronnet, Sophie Crozier Mortreux, Anne Léger, Laure Bottin, Sam Ghazanfari, Marion Yger, Stephen Delorme, Christine Vassilev, Clémence Blanc, Nader Sourour, Eimad Shotar, Stéphanie Lenck, Kévin Premat, Julien Allard, Louisette Padra, Pierre-Marie Chiaroni, Antonio Rainone, Gaspard Gerschenfeld, Julien Ognard, François-Mathias Merrien, Denis Maréchal, Marie Bruguet, Philippe Goas, Sandrine Normant, Géraldine Viard, Mourad Cheddad El Aouni, Sophie Le Hir, Audrey Campos, Irina Viakhireva-Dovganuk, Christophe Rivière-Paya, Xavier Barreau, Jérôme Berge, Jean-Sébastien Liegey, Pierre Briau, Lisa Papillon, Jean Papaxanthos, Sabrina Debruxelles, Stéphane Olindo, Mathilde Poli, Pauline Renou, Victoire Lyon, Aurélie Boyer, Sharmila Sagnier, Thomas Tourdias, Thomas Courret, Malgorzata Milnerowicz, Tristan Kerdraon, Lisa Saleille, Camille Dallies-Labourdette, Léa Donnadieu, Sylvain Ledure, Anne-Christine Januel, Fabrice Bonneville, Guillaume Bellanger, Philippe Tall, Federico Sacchetti, Jean-Marc Olivot, Lionel Calviere, Alain Viguier, Jean-François Albucher, Charlotte Periole, Nicolas Raposo, Gabrielle Sill, Hélène Catala, Laurent Derex, Julia Fontaine, Laura Mechtouff, Norbert Nighoghossian, Elodie Ong, Lucie Rascle, Roberto Riva, Francis Turjman, Morgane Laubacher, Mehdi Beyragued, Yves Berthezene, Marc Hermier, Ameli Roxanna, Alexandre Bani-Sadr, Andrea Filip, Matteo Cappucci, Adeline Mansuy, Apolline Barbe, Morgane Bouin, Ricardo Moreno-Gomez, Daniel Pontal, Quentin Fleury, Romain Bourcier, Hubert Desal, Benjamin Daumas-Duport, Guillaume Tessier, Arthur Lionnet, Benoît Guillon, Simon Lassoze, Pacôme Constant Dit Beaufils, Cédric Lenoble, Cécile Preterre, Cyril Dargazanli, Isabelle Mourand, Lucas Corti, Adrien ter Schiphorst, Federico Cagnazzo, Imad Derraz, Mehdi Mahmoudi, Pierre-Henri Lefevre, Grégory Gascou, François-Louis Collemiche, Quentin Varnier, Sophie Huby, Mahmoud Charif, Pauline Prin, Thibaut Roux, Arthur Attal, Justine Petitfour, Cédric Turpinat, Thomas Checkouri, Jonathan Cortese, Jildaz Caroff, Vanessa Chalumeau, Cristian Mihalea, Nicolas Legris, Augustin Ozanne, Leon Ikka, Olivier Chassin, Sophie Gallas, Laura Venditti, Mariana Sarov-Rivière, Mihaela Husleag, Julien Ducasse, Mathieu Vieira, Julien Cogez, Sophie Guettier, Estelle La Porte, Jean Bouchart, Damien Chevanne, Maxime Gauberti, Grégoire Braux, Mohammad Ismail, Mohamad Fadi Salkine, Romain Schneckenburger, Laurent Pierot, Vi Tuan Hua, Paolo Pagano, Alexandre Doucet, Christophe Gelmini, Pierre-François Manceau, Laurentiu Paiusan, Isabelle Serre, Thi Ngoc Phuong Nguyen, Maher Sahnoun, Nathalie Caucheteux, Gwendoline Arnoult, Siwar Ayari, Christophe Portefaix, Margaux Bonnaire, Abderrahim Zerroug, Ricardo Moreno, Elie Lteif, Pauline Paris, Nathalie Bourgois, Marie Raquin, Géraud Forestier, Ludovic Blanchard, Stéphane Velasco, Samy Boucebci, Nicolas Raynaud, Victor Dumas, Jean-Philippe Neau, Céline Thomarat, Mélodie Pillet, Séverine Laurin, Nathalie Nasr, Mathilde Dupin, Ayoub Guerrab, Héloïse Ifergan, Grégoire Boulouis, Richard Bibi, Denis Herbreteau, Clémence Hoche, Arnaud Bretonnière, Marie Gaudron, Élisabeth Molinier, Kevin Janot, Vladimir Charron, Abderrahim El Houfia, Elodie Barritaud, Nicolas Charron, Mariam Annan, Séverine Debiais, Thomas Personnic, Martin Bretzner, Nelly Dequatre, Marie Bodenant, Laurent Puy, François Caparros, Lucie Dellaschiava, Kaelig Watel, Thomas Accettone, Adrien Marchal, Firas Farhat, Anceline Dong, Frédéric Faugeras, Luca Scarcia, Erwah Kalsoum, Jean-Philippe Desilles, Raphaël Blanc, Michel Piotin, Simon Escalard, Humain Baharvahdath, Hocine Redjem, Amira Al Raaisi, Stanislas Smajda, Erwan Robichon, Arthur Gutter, Benjamin Maïer, Grace Adwane, Aurelien Freiherr von Seckendorff, Cristina Hobeanu, Ada Boutelier, Pierre Seners, Christelle Nilles, Igor Raynouard, Nefeli Valyraki, Charon Christophe
Abstract Small GTPases of the Ras superfamily act as molecular switches cycling between GDP-bound inactive and GTP-bound active states. Their signaling output depends not only on GTP loading but on continuous nucleotide cycling controlled by guanine…
Shah Wajed, Yann Ferrandez, Mahel Zeghouf, Rasta Ghasemi, Cylia Puertas, Agata Nawrotek, Franck Gesbert
Antibiotic combinations are an attractive strategy to maximise the efficiency of drug treatment and minimise resistance evolution, but we still lack a full understanding of their effect on bacterial cells. The interaction between DNA-targeting…
James Broughton, Achille Fraisse, Meriem El Karoui
Single-cell technologies have led to many insights on the function of individual cells within populations. Time-series data, in particular, have become increasingly adopted to uncover the molecular basis of heterogeneity in processes such as gene…
Achille Fraisse, Diego A Oyarzún, Meriem El Karoui
Clostridioides difficile is an enteropathogen responsible for diarrhea under conditions leading to a dysbiosis of the gut microbiota, in particular after an antibiotic treatment. It is a spore-forming obligate anaerobe, which is, as such, usually…
Repairing DNA damage is of primary importance for all living organisms. DNA double-strand breaks (DSBs) are one of the most serious types of DNA damage, as they lead to loss of genetic information and death when not repaired. In E. coli , they are…
Daniel Thédié, Alessia Lepore, Lorna Mclaren, Meriem El Karoui
HIV-1 infection triggers multiple cellular pathways that modulate viral replication and may promote latency. Central to this process is the reverse transcription of the viral RNA into DNA and its integration into host chromatin, both processes being…
Delphine Lapaillerie, Camille Tumiotto, Viviana Scoca, Suzanne Figueiredo, Mathieu Maisch, Carole Bertinetti, Marylene Mougel, Fabrice Fleury, Paul Lesbats, Olivier Delelis, Jacques Dutrieux, Francesca Di Nunzio, Vincent Parissi
