Consulter le flux RSS

Publications

Affichage des publications 1 à 10 sur 173 au total

Neurosciences

Mechanical Thrombectomy in Ischemic Stroke With a Medium or Distal Arterial Occlusion: The DISCOUNT Randomized Clinical Trial

Importance Evidence regarding efficacy and safety of thrombectomy in acute ischemic stroke (AIS) due to medium or distal vessel occlusions (MDVOs) is lacking. Objective To evaluate the benefit of thrombectomy, in addition to medical treatment over…

Frédéric Clarençon, Fouzi Bala, Amandine Baptiste, Marco Pasi, Gaultier Marnat, Igor Sibon, Benjamin Gory, Sébastien Richard, Raoul Pop, Valérie Wolff, Cédric Fauché, Matthias Lamy, Vincent Costalat, Caroline Arquizan, Christine Rodriguez-Régent, Guillaume Turc, Christophe Cognard, Louis Fontaine, Federico Di Maria, Bertrand Lapergue, Nicolas Bricout, Hilde Henon, Titien Tuilier, Aymeric Wittwer, Pierre Louis Alexandre, Solène de Gaalon, Laurent Spelle, Christian Denier, Emmanuel Chabert, Anna Ferrier, Aymeric Rouchaud, Francisco Macian-Montoro, Sébastien Soize, Solène Moulin, William Boisseau, Candice Sabben, Charlotte Barbier, Marion Boulanger, Omer Faruk Eker, Tae-Hee Cho, Jean-Christophe Gentric, Serge Timsit, Marc-Antoine Labeyrie, Peggy Reiner, Fernando Pico, Isabelle Durand-Zaleski, Sonia Alamowitch, Agnès Dechartres

JAMA Cardiology -

Organisation et fonctions cellulaires

The cytokinesis regulator RacGAP1 is a Rac1‐specific GAP on membranes

Rho family small GTPases are essential for cytokinesis completion. RacGAP1, a dimeric multidomain protein with a lipid‐binding C1 domain and a GTPase‐activating protein (GAP) domain, is a major regulator in this process. However, despite many…

Pavlina Dubois, Yann Ferrandez, Clara Rey, Cyril Pages, Agata Nawrotek, Jacqueline Cherfils

Protein Science -

Sciences du Vivant

Persistence without turnover: the RhoG G12E mutant highlights the role of nucleotide cycling in RhoG signaling

Abstract Small GTPases of the Ras superfamily act as molecular switches cycling between GDP-bound inactive and GTP-bound active states. Their signaling output depends not only on GTP loading but on continuous nucleotide cycling controlled by guanine…

Shah Wajed, Yann Ferrandez, Mahel Zeghouf, Rasta Ghasemi, Cylia Puertas, Agata Nawrotek, Franck Gesbert

Biochemical Journal -

Bactériologie

Working with C. difficile in a Hypoxic Chamber

Clostridioides difficile is an enteropathogen responsible for diarrhea under conditions leading to a dysbiosis of the gut microbiota, in particular after an antibiotic treatment. It is a spore-forming obligate anaerobe, which is, as such, usually…

Léo Caulat, Aurélie Lotoux, Isabelle Martin-Verstraete, Claire Morvan

Clostridioides difficile -

Sciences du Vivant

BRCA1-RAD51 homologous DNA repair pathway promotes HIV-1 reverse transcription

HIV-1 infection triggers multiple cellular pathways that modulate viral replication and may promote latency. Central to this process is the reverse transcription of the viral RNA into DNA and its integration into host chromatin, both processes being…

Delphine Lapaillerie, Camille Tumiotto, Viviana Scoca, Suzanne Figueiredo, Mathieu Maisch, Carole Bertinetti, Marylene Mougel, Fabrice Fleury, Paul Lesbats, Olivier Delelis, Jacques Dutrieux, Francesca Di Nunzio, Vincent Parissi

Science Advances -