Publications

Bactériologie

Improving electrochemical aptasensor sensitivity for Bacillus cereus spore detection in food safety applications

Rapid detection of Bacillus cereus spores is essential for preventing food contamination and spoilage. Many existing methods detect B. cereus vegetative cells rather than spores and cannot be applied directly to foods. Here, we present a combination…

Milica Sentic, Francesco Rizzotto, Zorica Novakovic, Aleksandar Karajic, Brahim Heddi, Jasmina Vidic

Talanta - 2026

Chimie

Breaking Bonds by Light: The Absorbance–Fragmentation Paradox

Abstract Multi‐branched probes based on 2‐hydroxymethylene 8‐dimethylaminoquinoline (8‐DMAQ) and triphenylamine (TPA) have been synthesized and compared under UV and femtosecond near‐infrared two‐photon (2P) activation conditions. While octupolar (…

Petra Dunkel, Christine Tran, Delphine Rigault, Bence Kontra, Eric Deprez, Patrick Tauc, Zoltán Mucsi, Hamid Dhimane, Peter Dalko

Chemistry - A European Journal - 2025

Chimie

Breaking Bonds by Light: The Absorbance–Fragmentation Paradox

Abstract Multi‐branched probes based on 2‐hydroxymethylene 8‐dimethylaminoquinoline (8‐DMAQ) and triphenylamine (TPA) have been synthesized and compared under UV and femtosecond near‐infrared two‐photon (2P) activation conditions. While octupolar (…

Petra Dunkel, Christine Tran, Delphine Rigault, Bence Kontra, Eric Deprez, Patrick Tauc, Zoltán Mucsi, Hamid Dhimane, Peter Dalko

Chemistry - A European Journal - 2025

Amélioration des plantes

NAL1 forms a molecular cage to regulate FZP phase separation

NARROW LEAF 1 ( NAL1 ), originally identified for its role in shaping leaf morphology, plant architecture, and various agronomic traits in rice, has remained enigmatic in terms of the molecular mechanisms governing its multifaceted functions. In…

Ling-Yun Huang, Ting-Ting Wang, Peng-Tao Shi, Ze-Yu Song, Wei-Fei Chen, Na-Nv Liu, Xia Ai, Hai-Hong Li, Xi-Miao Hou, Li-Bing Wang, Kun-Ming Chen, Stephane Rety, Xu-Guang Xi

Proceedings of the National Academy of Sciences of the United States of America - 2025

Virologie

Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases

There is a strong demand for new and efficient antiviral compounds. A series of 2-hydroxy-1,4-naphthoquinone Mannich bases were screened for their HIV-1-RNase H inhibitory activity. An HIV-1-RNase H assay was used to study the RNase H inhibition by…

Nhat Quang Tu, Clémence Richetta, Federica Putzu, Olivier Delelis, Khursheed Ahmed, Vijay H Masand, Rainer Schobert, Enzo Tramontano, Angela Corona, Bernhard Biersack

Molecules - 2025

Microbiologie et Parasitologie

Biotope-dependent High Level Resistance to Reactive Oxygen Species, Antibiotic Tolerance, and Virulence of Staphylococcus aureus

The human and livestock pathogen Staphylococcus aureus poses a major clinical challenge due to antibiotic treatment failure. Its resilience is mainly attributed to antibiotic resistance and tolerance mechanisms related to persistence. Here we…

Vincent Léguillier, Karine Gloux, Majd Khalife, Rochelle D’mello, Zoran Minic, Milica Sentic, Marta Catto, Marisa Manzano, Christine Péchoux, Sandrine Truchet, Philippe Gaudu, Christina Nielsen-Leroux, Brahim Heddi, Alexandra Gruss, Jasmina Vidic

Biochimie

Structural mechanism of RECQ1 helicase in unfolding G-quadruplexes compared with duplex DNA

RECQ1, the most abundant RecQ helicase in human cells, is involved in telomere maintenance in ALT cells and plays a critical role in maintaining genomic integrity and stability. Here, we present five high-resolution crystal structures that…

Ze-Yu Song, Xin Zhang, Xia Ai, Ling-Yun Huang, Xi-Miao Hou, Philippe Fossé, Na-Nv Liu, Olivier Mauffret, Stéphane Réty, Xu-Guang Xi

Nucleic Acids Research - 2025

Biologie structurale

An antiparallel G-quadruplex structure with a 5′-end overhang forms predominantly at the human telomeric ds–ss DNA junction

G-quadruplex structures formed by human telomeric sequences are highly sensitive to subtle sequence variations and local environment. While most structural studies have focused on sequences containing four uninterrupted G-tracts, the structural…

Constanza Avendano Avila, Brahim Heddi

Chemical Communications - 2025

Sciences du Vivant

Inhibition of HIV-1 replication by primer RNA packaging inhibitors

ABSTRACT An essential step in the life cycle of human immunodeficiency virus type 1 (HIV-1) is the packaging of tRNA 3 Lys during viral assembly. This step, which requires the assembly of a ternary complex consisting of GagPol, mitochondrial lysyl…

Marc Mirande, Frédéric Subra, Clémence Richetta, Eric Deprez, Olivier Delelis

mBio - 2025

Sciences du Vivant

Chaperone Activity of SARS-CoV-2 Nucleocapsid Protein: RNA Annealing and Destabilization Mechanisms

The recent global COVID-19 pandemic has prompted new research in coronaviruses. Despite the discovery of effective vaccines and therapeutic interventions, coronaviruses remain a threat to humans as the emergence of novel variants or new pathogenic…

Loussine Zargarian, Xia Ai, Ze-Yu Song, Lara Perez-Gorgol, Esteban Couprie-Diaz, Xu-Guang Xi, Olivier Mauffret, Philippe Fossé

Journal of Molecular Biology - 2025