Publications

Bactériologie

Phenotypic plasticity trade-offs in an age-structured model of bacterial growth under stress

Under low concentrations of antibiotics causing DNA damage, \textit{Escherichia coli} bacteria can trigger stochastically a stress response known as the SOS response. While the expression of this stress response can make individual cells transiently…

Meriem El Karoui, Ignacio Madrid, Sylvie Méléard

Sciences du Vivant

In Vitro and In Silico Evaluation of the Anti-Infective Potential of EF24-Analogous Curcuminoids: Antiprotozoal Activity and HIV-1 Ribonuclease H Inhibition

Curcumin derivatives (curcuminoids) exhibit considerable antiparasitic and antiviral activities. In this study, EF24-like bis-2-fluorobenzylidene piperidone derivatives were synthesized and evaluated for antiprotozoal activity and inhibition of the…

Tariq Khan, Ibrahim Al Nasr, Waleed Koko, Kamal Qureshi, Nhat Quang Tu, Clémence Richetta, Federica Putzu, Laura Dettori, Olivier Delelis, Rainer Schobert, Angela Corona, Bernhard Biersack

Pathogens - 2026

Sciences du Vivant

Effect of TAR hairpin stabilization on HIV-1 reverse transcription

ABSTRACT Reverse transcription of the human immunodeficiency virus type 1 (HIV-1) genome requires the first strand transfer that relies on a base-pairing interaction between the 3′ R sequence of the genomic RNA (gRNA) and the r sequence of the…

Sandra da Silva Amaral, Clémence Richetta, Lola Oualid, Nhat Quang Tu, Brigitte René, Olivier Mauffret, Olivier Delelis, Philippe Fossé

Journal of Virology - 2026

Sciences du Vivant

Biotope-dependent resistance to reactive oxygen species, antibiotic tolerance, and virulence of Staphylococcus aureus

Abstract The human and livestock pathogen Staphylococcus aureus poses a major clinical challenge due to antibiotic treatment failure. Its resilience is mainly attributed to antibiotic resistance and tolerance mechanisms related to persistence. Here…

Vincent Léguillier, Karine Gloux, Majd Khalife, Rochelle D’mello, Zoran Minic, Milica Sentic, Marta Catto, Marisa Manzano, Christine Péchoux, Sandrine Truchet, Philippe Gaudu, Christina Nielsen-Leroux, Brahim Heddi, Alexandra Gruss, Jasmina Vidic

Communications Biology - 2026

Neurosciences

Mechanical Thrombectomy in Ischemic Stroke With a Medium or Distal Arterial Occlusion: The DISCOUNT Randomized Clinical Trial

Importance Evidence regarding efficacy and safety of thrombectomy in acute ischemic stroke (AIS) due to medium or distal vessel occlusions (MDVOs) is lacking. Objective To evaluate the benefit of thrombectomy, in addition to medical treatment over…

Frédéric Clarençon, Fouzi Bala, Amandine Baptiste, Marco Pasi, Gaultier Marnat, Igor Sibon, Benjamin Gory, Sébastien Richard, Raoul Pop, Valérie Wolff, Cédric Fauché, Matthias Lamy, Vincent Costalat, Caroline Arquizan, Christine Rodriguez-Régent, Guillaume Turc, Christophe Cognard, Louis Fontaine, Federico Di Maria, Bertrand Lapergue, Nicolas Bricout, Hilde Henon, Titien Tuilier, Aymeric Wittwer, Pierre Louis Alexandre, Solène de Gaalon, Laurent Spelle, Christian Denier, Emmanuel Chabert, Anna Ferrier, Aymeric Rouchaud, Francisco Macian-Montoro, Sébastien Soize, Solène Moulin, William Boisseau, Candice Sabben, Charlotte Barbier, Marion Boulanger, Omer Faruk Eker, Tae-Hee Cho, Jean-Christophe Gentric, Serge Timsit, Marc-Antoine Labeyrie, Peggy Reiner, Fernando Pico, Isabelle Durand-Zaleski, Sonia Alamowitch, Agnès Dechartres

JAMA Cardiology - 2026

Organisation et fonctions cellulaires

The cytokinesis regulator RacGAP1 is a Rac1‐specific GAP on membranes

Rho family small GTPases are essential for cytokinesis completion. RacGAP1, a dimeric multidomain protein with a lipid‐binding C1 domain and a GTPase‐activating protein (GAP) domain, is a major regulator in this process. However, despite many…

Pavlina Dubois, Yann Ferrandez, Clara Rey, Cyril Pages, Agata Nawrotek, Jacqueline Cherfils

Protein Science - 2026

Sciences du Vivant

Persistence without turnover: the RhoG G12E mutant highlights the role of nucleotide cycling in RhoG signaling

Abstract Small GTPases of the Ras superfamily act as molecular switches cycling between GDP-bound inactive and GTP-bound active states. Their signaling output depends not only on GTP loading but on continuous nucleotide cycling controlled by guanine…

Shah Wajed, Yann Ferrandez, Mahel Zeghouf, Rasta Ghasemi, Cylia Puertas, Agata Nawrotek, Franck Gesbert

Biochemical Journal - 2026

Sciences du Vivant

Suppression of bacterial cell death underlies the antagonistic interaction between ciprofloxacin and tetracycline in<i>Escherichia coli</i>

Antibiotic combinations are an attractive strategy to maximise the efficiency of drug treatment and minimise resistance evolution, but we still lack a full understanding of their effect on bacterial cells. The interaction between DNA-targeting…

James Broughton, Achille Fraisse, Meriem El Karoui

Nucleic Acids Research - 2026

Sciences du Vivant

Representation learning of single-cell time-series with deep variational autoencoders

Single-cell technologies have led to many insights on the function of individual cells within populations. Time-series data, in particular, have become increasingly adopted to uncover the molecular basis of heterogeneity in processes such as gene…

Achille Fraisse, Diego A Oyarzún, Meriem El Karoui

Bactériologie

Working with C. difficile in a Hypoxic Chamber

Clostridioides difficile is an enteropathogen responsible for diarrhea under conditions leading to a dysbiosis of the gut microbiota, in particular after an antibiotic treatment. It is a spore-forming obligate anaerobe, which is, as such, usually…

Léo Caulat, Aurélie Lotoux, Isabelle Martin-Verstraete, Claire Morvan

Clostridioides difficile - 2026