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Publications

Affichage des publications 31 à 40 sur 139 au total

Pharmacologie

Different Pathways Conferring Integrase Strand-Transfer Inhibitors Resistance

Integrase Strand Transfer Inhibitors (INSTIs) are currently used as the most effective therapy in the treatment of human immunodeficiency virus (HIV) infections. Raltegravir (RAL) and Elvitegravir (EVG), the first generation of INSTIs used…

Clémence Richetta, Nhat Quang Tu, Olivier Delelis

Viruses -

Sciences du Vivant

Differential activation of human neutrophils by SARS-CoV-2 variants of concern

The emerging SARS-CoV-2 virus has affected the entire world with over 600 million confirmed cases and 6.5 million deaths as of September 2022. Since the beginning of the pandemic, several variants of SARS-CoV-2 have emerged, with different…

Samuel Lebourgeois, Ambroise David, Houssem Redha Chenane, Vanessa Granger, Reyene Menidjel, Nadhira Fidouh, Benoît Noël, Olivier Delelis, Clémence Richetta, Charlotte Charpentier, Sylvie Chollet-Martin, Diane Descamps, Benoit Visseaux, Luc de Chaisemartin

Frontiers in Immunology -

Sciences du Vivant

Cryo–electron microscopy unveils unique structural features of the human Kir2.1 channel

We present the first structure of the human Kir2.1 channel containing both transmembrane domain (TMD) and cytoplasmic domain (CTD). Kir2.1 channels are strongly inward-rectifying potassium channels that play a key role in maintaining resting…

Carlos Fernandes, Dania Zuniga, Charline Fagnen, Valérie Kugler, Rosa Scala, Gérard Péhau-Arnaudet, Renaud Wagner, David Perahia, Saïd Bendahhou, Catherine Vénien-Bryan

Science Advances -

Sciences du Vivant

The convergence of head-on DNA unwinding forks induces helicase oligomerization and activity transition

Significance Bloom syndrome helicase (BLM) is a multifunctional helicase that primarily catalyzes the separation of two single strands of DNA. Here, using a single-molecule optical tweezers approach combined with confocal microscopy, we monitored…

Lulu Bi, Zhenheng Qin, Teng Wang, Yanan Li, Xinshuo Jia, Xia Zhang, Xi-Miao Hou, Mauro Modesti, Xu-Guang Xi, Bo Sun

Proceedings of the National Academy of Sciences of the United States of America -

Sciences du Vivant

The Autophagy Receptor TAX1BP1 ( T6BP ) improves antigen presentation by MHC‐II molecules

CD4 + T lymphocytes play a major role in the establishment and maintenance of immunity. They are activated by antigenic peptides derived from extracellular or newly synthesized (endogenous) proteins presented by the MHC-II molecules. The pathways…

Gabriela Sarango, Clémence Richetta, Mathias Pereira, Anita Kumari, Michael Ghosh, Lisa Bertrand, Cédric Pionneau, Morgane Le Gall, Sylvie Grégoire, Raphaël Jeger-Madiot, Elina Rosoy, Frédéric Subra, Olivier Delelis, Mathias Faure, Audrey Esclatine, Stéphanie Graff‐dubois, Stefan Stevanović, Bénédicte Manoury, Bertha Cecilia Ramirez, Arnaud Moris

EMBO Reports -

Sciences du Vivant

Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates

Bloom syndrome protein (BLM) is a conserved RecQ family helicase involved in the maintenance of genome stability. BLM has been widely recognized as a genome "caretaker" that processes structured DNA. In contrast, our knowledge of how BLM behaves on…

Teng Wang, Jiaojiao Hu, Yanan Li, Lulu Bi, Lijuan Guo, Xinshuo Jia, Xia Zhang, Dan Li, Xi‐miao Hou, Mauro Modesti, Xu‐guang Xi, Cong Liu, Bo Sun

Angewandte Chemie International Edition -

Sciences du Vivant

The convergence of head-on DNA unwinding forks induces helicase oligomerization and activity transition

Significance Bloom syndrome helicase (BLM) is a multifunctional helicase that primarily catalyzes the separation of two single strands of DNA. Here, using a single-molecule optical tweezers approach combined with confocal microscopy, we monitored…

Lulu Bi, Zhenheng Qin, Teng Wang, Yanan Li, Xinshuo Jia, Xia Zhang, Xi-Miao Hou, Mauro Modesti, Xu-Guang Xi, Bo Sun

Proceedings of the National Academy of Sciences of the United States of America -

Cancer

The Autophagy Receptor TAX1BP1 ( T6BP ) improves antigen presentation by MHC‐II molecules

Gabriela Sarango, Clémence Richetta, Mathias Pereira, Anita Kumari, Michael Ghosh, Lisa Bertrand, Cédric Pionneau, Morgane Le Gall, Sylvie Grégoire, Raphaël Jeger-Madiot, Elina Rosoy, Frédéric Subra, Olivier Delelis, Mathias Faure, Audrey Esclatine, Stéphanie Graff-Dubois, Stefan Stevanović, Bénédicte Manoury, Bertha Cecilia Ramirez, Arnaud Moris

EMBO Reports -