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Publications

Affichage des publications 21 à 30 sur 144 au total

Sciences du Vivant

Nonstructural N- and C-tails of Dbp2 confer the protein full helicase activities.

Human DDX5 and its yeast ortholog Dbp2 are ATP-dependent RNA helicases that play a key role in normal cell processes, cancer development, and viral infection. The crystal structure of the RecA1-like domain of DDX5 is available but the global…

Song Qx, Liu Nn, Liu Zx, Zhang Yz, Rety S, Hou Xm, Xi Xg

J. Biol. Chem. -

Sciences du Vivant

Direct single cell observation of a key E. coli cell cycle oscillator

A long-standing hypothesis sees DNA replication control in E. coli as a central cell cycle os-cillator at whose core is the DnaA protein. The consensus is that the activity of the DnaA protein, which is dependent on its nucleotide bound state, is an…

Ilaria Iuliani, Gladys Mbemba, Marco Cosentino Lagomarsino, Bianca Sclavi

Biologie structurale

MDexciteR: Enhanced Sampling Molecular Dynamics by Excited Normal Modes or Principal Components Obtained from Experiments

Molecular dynamics with excited normal modes (MDeNM) is an enhanced sampling method for exploring conformational changes in proteins with minimal biases. The excitation corresponds to injecting kinetic energy along normal modes describing intrinsic…

Mauricio Costa, Paulo R Batista, Antoniel Gomes, Leonardo S Bastos, Maxime Louet, Nicolas Floquet, Paulo M Bisch, David Perahia

Journal of Chemical Theory and Computation -

Chimie

Shigella IpaA mediates actin bundling through diffusible vinculin oligomers with activation imprint

Upon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating ligands classically disrupt intramolecular interactions between the vinculin head and tail domains that bind to actin filaments. Here, we show that Shigella…

Cesar Valencia-Gallardo, Daniel-Isui Aguilar-Salvador, Hamed Khakzad, Benjamin Cocom-Chan, Charles Bou-Nader, Christophe Velours, Yosra Zarrouk, Christophe Le Clainche, Christian Malosse, Diogo Borges Lima, Nicole Quenech’du, Bilal Mazhar, Sami Essid, Marc Fontecave, Atef Asnacios, Julia Chamot-Rooke, Lars Malmström, Guy Tran van Nhieu

Cell Reports -

Sciences du Vivant

Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

ABSTRACT Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA…

E. Mauro, D. Lapaillerie, C. Tumiotto, C. Charlier, F. Martins, S. Sousa, M. Métifiot, P. Weigel, K. Yamatsugu, M. Kanai, H. Munier-Lehmann, C. Richetta, M. Maisch, J. Dutrieux, J. Batisse, M. Ruff, O. Delelis, P. Lesbats, V. Parissi

mBio -

Biochimie, Biologie Moléculaire

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of…

Candice Sartre, François Peurois, Marie Ley, Marie-Hélène Kryszke, Wenhua Zhang, Delphine Courilleau, Rodolphe Fischmeister, Yves Ambroise, Mahel Zeghouf, Sarah Cianférani, Yann Ferrandez, Jacqueline Cherfils

Nature Communications -

Sciences du Vivant

The Autophagy Receptor TAX1BP1 ( T6BP ) improves antigen presentation by MHC‐II molecules

Gabriela Sarango, Clémence Richetta, Mathias Pereira, Anita Kumari, Michael Ghosh, Lisa Bertrand, Cédric Pionneau, Morgane Le Gall, Sylvie Grégoire, Raphaël Jeger-Madiot, Elina Rosoy, Frédéric Subra, Olivier Delelis, Mathias Faure, Audrey Esclatine, Stéphanie Graff-Dubois, Stefan Stevanović, Bénédicte Manoury, Bertha Cecilia Ramirez, Arnaud Moris

EMBO Reports -