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Publications

Affichage des publications 21 à 30 sur 136 au total

Biochimie, Biologie Moléculaire

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of…

Candice Sartre, François Peurois, Marie Ley, Marie-Hélène Kryszke, Wenhua Zhang, Delphine Courilleau, Rodolphe Fischmeister, Yves Ambroise, Mahel Zeghouf, Sarah Cianférani, Yann Ferrandez, Jacqueline Cherfils

Nature Communications -

Génétique humaine

Nucleosome assembly and disassembly pathways in vitro

Structural fluctuations of nucleosomes modulate the access to internal DNA in eukaryotic cells; clearly characterisation of this fundamental process is crucial to understanding gene regulation. Here we apply PhAST (Photochemical Analysis of…

Akiko Hatakeyama, Yuliia Shymko, Brigitte Hartmann, Romain Retureau, Claude Nogues, Marco Pasi, Malcolm Buckle

PLoS ONE -

Sciences du Vivant

The Autophagy Receptor TAX1BP1 ( T6BP ) improves antigen presentation by MHC‐II molecules

Gabriela Sarango, Clémence Richetta, Mathias Pereira, Anita Kumari, Michael Ghosh, Lisa Bertrand, Cédric Pionneau, Morgane Le Gall, Sylvie Grégoire, Raphaël Jeger-Madiot, Elina Rosoy, Frédéric Subra, Olivier Delelis, Mathias Faure, Audrey Esclatine, Stéphanie Graff-Dubois, Stefan Stevanović, Bénédicte Manoury, Bertha Cecilia Ramirez, Arnaud Moris

EMBO Reports -

Pharmacologie

Different Pathways Conferring Integrase Strand-Transfer Inhibitors Resistance

Integrase Strand Transfer Inhibitors (INSTIs) are currently used as the most effective therapy in the treatment of human immunodeficiency virus (HIV) infections. Raltegravir (RAL) and Elvitegravir (EVG), the first generation of INSTIs used…

Clémence Richetta, Nhat Quang Tu, Olivier Delelis

Viruses -

Sciences du Vivant

Differential activation of human neutrophils by SARS-CoV-2 variants of concern

The emerging SARS-CoV-2 virus has affected the entire world with over 600 million confirmed cases and 6.5 million deaths as of September 2022. Since the beginning of the pandemic, several variants of SARS-CoV-2 have emerged, with different…

Samuel Lebourgeois, Ambroise David, Houssem Redha Chenane, Vanessa Granger, Reyene Menidjel, Nadhira Fidouh, Benoît Noël, Olivier Delelis, Clémence Richetta, Charlotte Charpentier, Sylvie Chollet-Martin, Diane Descamps, Benoit Visseaux, Luc de Chaisemartin

Frontiers in Immunology -

Sciences du Vivant

Cryo–electron microscopy unveils unique structural features of the human Kir2.1 channel

We present the first structure of the human Kir2.1 channel containing both transmembrane domain (TMD) and cytoplasmic domain (CTD). Kir2.1 channels are strongly inward-rectifying potassium channels that play a key role in maintaining resting…

Carlos Fernandes, Dania Zuniga, Charline Fagnen, Valérie Kugler, Rosa Scala, Gérard Péhau-Arnaudet, Renaud Wagner, David Perahia, Saïd Bendahhou, Catherine Vénien-Bryan

Science Advances -