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Publications

Affichage des publications 1 à 10 sur 144 au total

Sciences du Vivant

A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer

• A41 is a specific and reversible inhibitor of RAC proteins • A41 competes with guanine nucleotide binding • A41 blocks RAC1 activity and RAC1-dependent cell functions in cancer cells • A41 exhibits anti-metastatic effects and increase of the…

Florian Dilasser, Lindsay Rose, Agnès Quemener, Yann Ferrandez, Dorian Hassoun, Morgane Rousselle, Hugo Bergereau, Séverine Marionneau Lambot, Luciano E Anselmino, Camille Trouillet, Gwennan Andre, Mike Maillasson, Mikael Croyal, Matthieu Riviere, Didier Dubreuil, Sylvain Collet, Frédérique Souaze, Mario Campone, Anne Patsouris, Erwan Mortier, Mauricio Menacho Marquez, Philippe Juin, Jacques Lebreton, Arnaud Tessier, Jacqueline Cherfils, Gervaise Loirand, Vincent Sauzeau

Cell Reports Medicine -

Sciences du Vivant

Recent Advances in Aptamer-Based Biosensors for Bacterial Detection

The rapid and sensitive detection of pathogenic bacteria is becoming increasingly important for the timely prevention of contamination and the treatment of infections. Biosensors based on nucleic acid aptamers, integrated with optical,…

Vincent Léguillier, Brahim Heddi, Jasmina Vidic

Biosensors -

Biologie structurale

Extended Sampling of Macromolecular Conformations from Uniformly Distributed Points on Multidimensional Normal Mode Hyperspheres

Proteins are dynamic entities that adopt diverse conformations, which play a pivotal role in their function. Understanding these conformations is essential, and protein collective motions, particularly those captured by normal mode (NM) and their…

Antoniel A S. Gomes, Mauricio G S Costa, Maxime Louet, Nicolas Floquet, Paulo M Bisch, David Perahia

Journal of Chemical Theory and Computation -

Biophysique

Interlocking G-Quadruplexes Using a G-Triad•G Connection: Implications for G-Wire Assembly

G-quadruplexes are noncanonical structures of nucleic acids formed mainly by G-rich sequences and play crucial roles in important cellular processes. They are also increasingly used in nanotechnology for their valuable properties. Various unexpected…

Abhishek Singh, Fernaldo Richtia Winnerdy, Constanza Avendaño Avila, Claude Nogues, Anh Tuân Phan, Brahim Heddi

Journal of the American Chemical Society -

Sciences du Vivant

Insulation of ribosomal promoter activity by Fis, H-NS or a divergent promoter within the packed E. coli genome.

Gene expression in bacterial cells is dependent on a gene&prime s position along the genome, mainly because of the effects of neighbouring genes&prime expression, but also because of the local activity of nucleoid proteins, differing levels…

Elisa Brambilla, Malikmohamed Yousuf, Qing Zhang, Gladys Mbemba, Cyriane Oeuvray, Damel Mektepbayeva, Anne Olliver, Marco Cosentino Lagomarsino, Bianca Sclavi

Chimie

Triphenylamine Sensitized 8‐Dimethylaminoquinoline: An Efficient Two‐Photon Caging Group for Intracellular Delivery

Abstract Triphenylamine‐sensitized 8‐dimethylaminoquinoline (TAQ) probes showed fair two‐photon absorption and fragmentation cross sections in releasing kainate and GABA ligands. The water‐soluble PEG and TEG‐analogs allowed cell internalization and…

Delphine Rigault, Philippe Nizard, Jonathan Daniel, Mireille Blanćhard-Desce, Patrick Tauc, Hamid Dhimane, Peter Dalko

Chemistry - A European Journal -

Biologie structurale

Stimulation of ATP Hydrolysis by ssDNA Provides the Necessary Mechanochemical Energy for G4 Unfolding

The G-quadruplex (G4) is a distinct geometric and electrophysical structure compared to classical doublestranded DNA, and its stability can impede essential cellular processes such as replication, transcription, and translation. This study focuses…

Yang-Xue Dai, Xiao-Lei Duan, Wen-Tong Fu, Shan Wang, Na-Nv Liu, Hai-Hong Li, Xia Ai, Hai-Lei Guo, Cel Areny Navés, Elisabeth Bugnard, Daniel Auguin, Xi-Miao Hou, Stephane Rety, Xu-Guang Xi

Journal of Molecular Biology -

Amélioration des plantes

The catalytic triad of rice NARROW LEAF1 involves H234

NARROW LEAF1 (NAL1) exerts a multifaceted influence on leaf morphology and crop yield. Recent crystal study proposed that histidine 233 (H233) is part of the catalytic triad. Here we report that unlike suggested previously, H234 instead of H233 is a…

Ling-Yun Huang, Na-Nv Liu, Wei-Fei Chen, Xia Ai, Hai-Hong Li, Ze-Lin Zhang, Xi-Miao Hou, Philippe Fossé, Olivier Mauffret, Dong-Sheng Lei, Stephane Rety, Xu-Guang Xi

Nature Plants -