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Showing posts 21 to 30 of 173 total

Sciences du Vivant

Inhibition of HIV-1 replication by primer RNA packaging inhibitors

ABSTRACT An essential step in the life cycle of human immunodeficiency virus type 1 (HIV-1) is the packaging of tRNA 3 Lys during viral assembly. This step, which requires the assembly of a ternary complex consisting of GagPol, mitochondrial lysyl…

Marc Mirande, Frédéric Subra, Clémence Richetta, Eric Deprez, Olivier Delelis

mBio -

Sciences du Vivant

A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer

• A41 is a specific and reversible inhibitor of RAC proteins • A41 competes with guanine nucleotide binding • A41 blocks RAC1 activity and RAC1-dependent cell functions in cancer cells • A41 exhibits anti-metastatic effects and increase of the…

Florian Dilasser, Lindsay Rose, Agnès Quemener, Yann Ferrandez, Dorian Hassoun, Morgane Rousselle, Hugo Bergereau, Séverine Marionneau Lambot, Luciano E Anselmino, Camille Trouillet, Gwennan Andre, Mike Maillasson, Mikael Croyal, Matthieu Riviere, Didier Dubreuil, Sylvain Collet, Frédérique Souaze, Mario Campone, Anne Patsouris, Erwan Mortier, Mauricio Menacho Marquez, Philippe Juin, Jacques Lebreton, Arnaud Tessier, Jacqueline Cherfils, Gervaise Loirand, Vincent Sauzeau

Cell Reports Medicine -

Analyse de données, Statistiques et Probabilités

Daily life in the Open Biologist’s second job, as a Data Curator

Background: Data reusability is the driving force of the research data life cycle. However, implementing strategies to generate reusable data from the data creation to the sharing stages is still a significant challenge. Even when datasets…

Livia C.T. Scorza, Tomasz Zieliński, Irina Kalita, Alessia Lepore, Meriem El Karoui, Andrew J Millar

Wellcome Open Research -

Cristallographie

Structural Basis for Parallel G-Quadruplex Recognition by an Ankyrin Protein

G-Quadruplex (G4) structures formed by guanine-rich DNA and RNA sequences are implicated in various biological processes. Understanding the mechanisms by which proteins recognize G4 structures is crucial for elucidating their functional roles. Here…

Khac Huy Ngo, Chong Wai Liew, Brahim Heddi, Anh Tuân Phan

Journal of the American Chemical Society -

Evolution

Estimating mutation rates under heterogeneous stress responses

Exposure to environmental stressors, including certain antibiotics, induces stress responses in bacteria. Some of these responses increase mutagenesis and thus potentially accelerate resistance evolution. Many studies report increased mutation rates…

Lucy Lansch-Justen, Meriem El Karoui, Helen K Alexander

PLoS Computational Biology -

Sciences du Vivant

Recent Advances in Aptamer-Based Biosensors for Bacterial Detection

The rapid and sensitive detection of pathogenic bacteria is becoming increasingly important for the timely prevention of contamination and the treatment of infections. Biosensors based on nucleic acid aptamers, integrated with optical,…

Vincent Léguillier, Brahim Heddi, Jasmina Vidic

Biosensors -

Biologie structurale

Extended Sampling of Macromolecular Conformations from Uniformly Distributed Points on Multidimensional Normal Mode Hyperspheres

Proteins are dynamic entities that adopt diverse conformations, which play a pivotal role in their function. Understanding these conformations is essential, and protein collective motions, particularly those captured by normal mode (NM) and their…

Antoniel A S. Gomes, Mauricio G S Costa, Maxime Louet, Nicolas Floquet, Paulo M Bisch, David Perahia

Journal of Chemical Theory and Computation -

Biophysique

Interlocking G-Quadruplexes Using a G-Triad•G Connection: Implications for G-Wire Assembly

G-quadruplexes are noncanonical structures of nucleic acids formed mainly by G-rich sequences and play crucial roles in important cellular processes. They are also increasingly used in nanotechnology for their valuable properties. Various unexpected…

Abhishek Singh, Fernaldo Richtia Winnerdy, Constanza Avendaño Avila, Claude Nogues, Anh Tuân Phan, Brahim Heddi

Journal of the American Chemical Society -