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Showing posts 11 to 20 of 174 total

Chimie

Radiation-induced synthesis of silver nanocomposites and their antibacterial applications

The global rise of antimicrobial resistance (AMR) poses a severe threat to public health, with multidrugresistant pathogens undermining the efficacy of conventional antibiotics. Silver nanoparticles (AgNPs) have emerged as promising broad-spectrum…

Wenbo Liu, Dominique Fourmy, Diana Dragoe, Hynd Remita, Ruxandra Gref

Scientific Reports -

Sciences du Vivant

Chaperone Activity of SARS-CoV-2 Nucleocapsid Protein: RNA Annealing and Destabilization Mechanisms

The recent global COVID-19 pandemic has prompted new research in coronaviruses. Despite the discovery of effective vaccines and therapeutic interventions, coronaviruses remain a threat to humans as the emergence of novel variants or new pathogenic…

Loussine Zargarian, Xia Ai, Ze-Yu Song, Lara Perez-Gorgol, Esteban Couprie-Diaz, Xu-Guang Xi, Olivier Mauffret, Philippe Fossé

Journal of Molecular Biology -

Chimie

Breaking Bonds by Light: The Absorbance–Fragmentation Paradox

Abstract Multi‐branched probes based on 2‐hydroxymethylene 8‐dimethylaminoquinoline (8‐DMAQ) and triphenylamine (TPA) have been synthesized and compared under UV and femtosecond near‐infrared two‐photon (2P) activation conditions. While octupolar (…

Petra Dunkel, Christine Tran, Delphine Rigault, Bence Kontra, Eric Deprez, Patrick Tauc, Zoltán Mucsi, Hamid Dhimane, Peter Dalko

Chemistry - A European Journal -

Chimie

Breaking Bonds by Light: The Absorbance–Fragmentation Paradox

Abstract Multi‐branched probes based on 2‐hydroxymethylene 8‐dimethylaminoquinoline (8‐DMAQ) and triphenylamine (TPA) have been synthesized and compared under UV and femtosecond near‐infrared two‐photon (2P) activation conditions. While octupolar (…

Petra Dunkel, Christine Tran, Delphine Rigault, Bence Kontra, Eric Deprez, Patrick Tauc, Zoltán Mucsi, Hamid Dhimane, Peter Dalko

Chemistry - A European Journal -

Amélioration des plantes

NAL1 forms a molecular cage to regulate FZP phase separation

NARROW LEAF 1 ( NAL1 ), originally identified for its role in shaping leaf morphology, plant architecture, and various agronomic traits in rice, has remained enigmatic in terms of the molecular mechanisms governing its multifaceted functions. In…

Ling-Yun Huang, Ting-Ting Wang, Peng-Tao Shi, Ze-Yu Song, Wei-Fei Chen, Na-Nv Liu, Xia Ai, Hai-Hong Li, Xi-Miao Hou, Li-Bing Wang, Kun-Ming Chen, Stephane Rety, Xu-Guang Xi

Proceedings of the National Academy of Sciences of the United States of America -

Virologie

Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases

There is a strong demand for new and efficient antiviral compounds. A series of 2-hydroxy-1,4-naphthoquinone Mannich bases were screened for their HIV-1-RNase H inhibitory activity. An HIV-1-RNase H assay was used to study the RNase H inhibition by…

Nhat Quang Tu, Clémence Richetta, Federica Putzu, Olivier Delelis, Khursheed Ahmed, Vijay H Masand, Rainer Schobert, Enzo Tramontano, Angela Corona, Bernhard Biersack

Molecules -

Microbiologie et Parasitologie

Biotope-dependent High Level Resistance to Reactive Oxygen Species, Antibiotic Tolerance, and Virulence of Staphylococcus aureus

The human and livestock pathogen Staphylococcus aureus poses a major clinical challenge due to antibiotic treatment failure. Its resilience is mainly attributed to antibiotic resistance and tolerance mechanisms related to persistence. Here we…

Vincent Léguillier, Karine Gloux, Majd Khalife, Rochelle D’mello, Zoran Minic, Milica Sentic, Marta Catto, Marisa Manzano, Christine Péchoux, Sandrine Truchet, Philippe Gaudu, Christina Nielsen-Leroux, Brahim Heddi, Alexandra Gruss, Jasmina Vidic