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Publications

Affichage des publications 51 à 60 sur 139 au total

Sciences du Vivant

Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates

Bloom syndrome protein (BLM) is a conserved RecQ family helicase involved in the maintenance of genome stability. BLM has been widely recognized as a genome "caretaker" that processes structured DNA. In contrast, our knowledge of how BLM behaves on…

Teng Wang, Jiaojiao Hu, Yanan Li, Lulu Bi, Lijuan Guo, Xinshuo Jia, Xia Zhang, Dan Li, Xi‐miao Hou, Mauro Modesti, Xu‐guang Xi, Cong Liu, Bo Sun

Angewandte Chemie International Edition -

Sciences du Vivant

Systemic inflammatory syndrome in children with FARSA deficiency

Variants in aminoacyl-tRNA synthetases (ARSs) genes are associated to a broad spectrum of human inherited diseases. Patients with defective PheRS, encoded by FARSA and FARSB, display brain abnormalities, interstitial lung disease and facial dys-…

Fabienne Charbit-Henrion, Roman Goguyer-Deschaumes, Keren Borensztajn, Marc Mirande, Jérémy Berthelet, Fernando Rodrigues-Lima, Anis Khiat, Marie‐louise Frémond, Brigitte Bader-Meunier, Marco Rodari, Luis Seabra, Gillian Rice, Marie Legendre, David Drummond, Laureline Berteloot, Charles‐joris Roux, Nathalie Boddaert, Philippe Drabent, Thierry Jo Molina, Florence Lacaille, Manoelle Kossorotoff, Nadine Cerf-Bensussan, Marianna Parlato, Alice Hadchouel

Clinical Genetics -

Bactériologie

Structural mechanism underpinning Thermus oshimai Pif1‐mediated G‐quadruplex unfolding

G-quadruplexes (G4s) are unusual stable DNA structures that cause genomic instability. To overcome the potential barriers formed by G4s, cells have evolved different families of proteins that unfold G4s. Pif1 is a DNA helicase from superfamily 1 …

Yang‐Xue Dai, Hai‐Lei Guo, Na‐Nv Liu, Wei‐Fei Chen, Xia Ai, Hai‐Hong Li, Bo Sun, Xi‐Miao Hou, Stephane Rety, Xu‐Guang Xi

EMBO Reports -

Chimie

FRET-mediated quenching of BODIPY fluorescent nanoparticles by methylene blue and its application to bacterial imaging

High resolution and good signal to noise ratio is a requirement in cell imaging. However, after labelling with fluorescent entities, and besides several washing steps, there is often an unwanted fluorescent background that reduces the images…

Yang Si, Chloé Grazon, Gilles Clavier, Jean-Frédéric Audibert, Bianca Sclavi, Rachel Meallet-Renault

Photochemical & Photobiological Sciences -

Sciences du Vivant

Investigation of the Low-Populated Excited States of the HIV-1 Nucleocapsid Domain

The nucleocapsid domain (NCd), located at the C-terminus of the HIV-1 Gag protein, is involved in numerous stages of the replication cycle, such as the packaging of the viral genome and reverse transcription. It exists under different forms through…

Assia Mouhand, Loussiné Zargarian, Anissa Belfetmi, Marjorie Catala, Marco Pasi, Ewen Lescop, Carine Tisné, Olivier Mauffret

Viruses -

Sciences du Vivant

Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain

ATP-sensitive potassium (K-ATP) channels are ubiquitously expressed on the plasma membrane of cells in several organs, including the heart, pancreas, and brain, and they govern a wide range of physiological processes. In pancreatic β-cells, K-ATP…

Charline Fagnen, Ludovic Bannwarth, Iman Oubella, Dania Zuniga, Ahmed Haouz, Eric Forest, Rosa Scala, Saïd Bendahhou, Rita de Zorzi, David Perahia, Catherine Vénien-Bryan

International Journal of Molecular Sciences -

Sciences du Vivant

Biochemistry, structure, and cellular internalization of a four nanobody‐bearing Fc dimer

VHH stands for the variable regions of heavy chain only of camelid IgGs. The VHH family forms a set of interesting proteins derived from antibodies that maintain their capacity to recognize the antigen, despite their relatively small molecular…

Eric Chabrol, Charline Fagnen, Sophie Landron, Estelle Marcheteau, Johann Stojko, Sophie‐pénélope Guenin, Mathias Antoine, Benjamin Fould, Gilles Ferry, Jean A Boutin, Catherine Vénien‐bryan

Protein Science -

Sciences de l'ingénieur

Influence of the Sequestration Effect of CTAB on the Biofunctionalization of Gold Nanorods

Gold nanorods (GNRs) can be functionalized with multiple biomolecules allowing efficient cell targeting and delivery into specific cells. However, various issues have to be addressed prior to any clinical applications. They involve controlled…

Henryk J Łaszewski, Bruno Palpant, Malcolm Buckle, Claude Nogues

ACS Applied Bio Materials -

Sciences du Vivant

Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations

Sulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a substrate. It has been previously suggested that a considerable shift of SULT…

Balint Dudas, Daniel Toth, David Perahia, Arnaud Nicot, Erika Balog, Maria Miteva

Scientific Reports -

Sciences du Vivant

Antitumor Activity and Mechanism of Action of Hormonotoxin, an LHRH Analog Conjugated to Dermaseptin-B2, a Multifunctional Antimicrobial Peptide

Prostate cancer is the most common cancer in men. For patients with advanced or metastatic prostate cancer, available treatments can slow down its progression but cannot cure it. The development of innovative drugs resulting from the exploration of…

Mickael Couty, Marie Dusaud, Mickael Miro-Padovani, Liuhui Zhang, Patricia Zadigue, Loussiné Zargarian, Olivier Lequin, Alexandre de la Taille, Jean Delbe, Yamina Hamma-Kourbali, Mohamed Amiche

International Journal of Molecular Sciences -