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Publications

Affichage des publications 71 à 80 sur 139 au total

Biologie structurale

Structural study of the function of Candida Albicans Pif1

Pif1 helicases, conserved in eukaryotes, are involved in maintaining genome stability in both the nucleus and mitochondria. Here, we report the crystal structure of a truncated Candida Albicans Pif1 (CaP-if1 368À883) in complex with ssDNA and an ATP…

Ke-Yu Lu, Ben-Ge Xin, Teng Zhang, Na-Nv Liu, Dan Li, Stephane Rety, Xu-Guang Xi

Biochemical and Biophysical Research Communications -

Bactériologie

Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition

Pif1 is an SF1B helicase that is evolutionarily conserved from bacteria to humans and plays multiple roles in maintaining genome stability in both nucleus and mitochondria. Though highly conserved, Pif1 family harbors a large mechanistic diversity…

Yang-Xue Dai, Wei-Fei Chen, Na-Nv Liu, Fang-Yuan Teng, Hai-Lei Guo, Xi-Miao Hou, Shuo-Xing Dou, Stephane Rety, Xu-Guang Xi

Nucleic Acids Research -

Urologie et Néphrologie

Antitumor Activity and Mechanism of Action of Hormonotoxin, an LHRH Analog Conjugated to Dermaseptin-B2, a Multifunctional Antimicrobial Peptide

Prostate cancer is the most common cancer in men. For patients with advanced or metastatic prostate cancer, available treatments can slow down its progression but cannot cure it. The development of innovative drugs resulting from the exploration of…

Mickael Couty, Marie Dusaud, Micka Miro-Padovani, Liuhui Zhan, Patricia Zadigue, Loussiné Zargarian, Olivier Lequin, Alexandre de La Taille, Jean Delbe, Yamina Hamma-Kourbali, Mohamed Amiche

International Journal of Molecular Sciences -

Mécanique des fluides

Out-of-Equilibrium Measurements of Kinetic Constants on a Biosensor

Conventional measurements of kinetic constants currently in use are performed at equilibrium and may require large volumes, especially at low association rate constant k on. If the measurements are made out of equilibrium, the values obtained may be…

Donatien Mottin, Florence Razan, Claude Nogues, Marie-Caroline Jullien

Analytical Chemistry -

Biochimie

Endogenous Bos taurus RECQL is predominantly monomeric and more active than oligomers

There is broad consensus that RecQ family helicase is a high-order oligomer that dissociates into a dimer upon ATP binding. This conclusion is based mainly on studies of highly purified recombinant proteins, and the oligomeric states of RecQ…

Na-Nv Liu, Ze-Yu Song, Hai-Lei Guo, Hu Yin, Wei-Fei Chen, Yang-Xue Dai, Ben-Ge Xin, Xia Ai, Lei Ji, Qing-Man Wang, Xi-Miao Hou, Shuo-Xing Dou, Stephane Rety, Xu-Guang Xi

Cell Reports -

Bactériologie

Threshold accumulation of a constitutive protein explains E. coli cell-division behavior in nutrient upshifts

Despite a boost of recent progress in dynamic single-cell measurements and analyses in Escherichia coli , we still lack a mechanistic understanding of the determinants of the decision to divide. Specifically, the debate is open regarding the…

Mia Panlilio, Jacopo Grilli, Giorgio Tallarico, Ilaria Iuliani, Bianca Sclavi, Pietro Cicuta, Marco Cosentino Lagomarsino

Proceedings of the National Academy of Sciences of the United States of America -

Biologie structurale

Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition

Pif1 is an SF1B helicase that is evolutionarily conserved from bacteria to humans and plays multiple roles in maintaining genome stability in both nucleus and mitochondria. Though highly conserved, Pif1 family harbors a large mechanistic diversity…

Yang-Xue Dai, Wei-Fei Chen, Na-Nv Liu, Fang-Yuan Teng, Hai-Lei Guo, Xi-Miao Hou, Shuo-Xing Dou, Stephane Rety, Xu-Guang Xi

Nucleic Acids Research -