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Publications

Affichage des publications 81 à 90 sur 170 au total

Sciences du Vivant

Investigation of the Low-Populated Excited States of the HIV-1 Nucleocapsid Domain

The nucleocapsid domain (NCd), located at the C-terminus of the HIV-1 Gag protein, is involved in numerous stages of the replication cycle, such as the packaging of the viral genome and reverse transcription. It exists under different forms through…

Assia Mouhand, Loussiné Zargarian, Anissa Belfetmi, Marjorie Catala, Marco Pasi, Ewen Lescop, Carine Tisné, Olivier Mauffret

Viruses -

Sciences du Vivant

Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain

ATP-sensitive potassium (K-ATP) channels are ubiquitously expressed on the plasma membrane of cells in several organs, including the heart, pancreas, and brain, and they govern a wide range of physiological processes. In pancreatic β-cells, K-ATP…

Charline Fagnen, Ludovic Bannwarth, Iman Oubella, Dania Zuniga, Ahmed Haouz, Eric Forest, Rosa Scala, Saïd Bendahhou, Rita de Zorzi, David Perahia, Catherine Vénien-Bryan

International Journal of Molecular Sciences -

Biologie structurale

Unprecedented hour-long residence time of a cation in a left-handed G-quadruplex

Cations are critical for the folding and assembly of nucleic acids. In G-quadruplex structures, cations can bind between stacked G-tetrads and coordinate with negatively charged guanine carbonyl oxygens. They usually exchange between binding sites…

Fernaldo Richtia Winnerdy, Blaž Bakalar, Poulomi Das, Brahim Heddi, Adrien Marchand, Frédéric Rosu, Valérie Gabelica, Anh Tuân Phan

Chemical Science -

Sciences du Vivant

Biochemistry, structure, and cellular internalization of a four nanobody‐bearing Fc dimer

VHH stands for the variable regions of heavy chain only of camelid IgGs. The VHH family forms a set of interesting proteins derived from antibodies that maintain their capacity to recognize the antigen, despite their relatively small molecular…

Eric Chabrol, Charline Fagnen, Sophie Landron, Estelle Marcheteau, Johann Stojko, Sophie‐pénélope Guenin, Mathias Antoine, Benjamin Fould, Gilles Ferry, Jean A Boutin, Catherine Vénien‐bryan

Protein Science -

Sciences de l'ingénieur

Influence of the Sequestration Effect of CTAB on the Biofunctionalization of Gold Nanorods

Gold nanorods (GNRs) can be functionalized with multiple biomolecules allowing efficient cell targeting and delivery into specific cells. However, various issues have to be addressed prior to any clinical applications. They involve controlled…

Henryk J Łaszewski, Bruno Palpant, Malcolm Buckle, Claude Nogues

ACS Applied Bio Materials -

Sciences du Vivant

Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations

Sulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a substrate. It has been previously suggested that a considerable shift of SULT…

Balint Dudas, Daniel Toth, David Perahia, Arnaud Nicot, Erika Balog, Maria Miteva

Scientific Reports -

Sciences du Vivant

Antitumor Activity and Mechanism of Action of Hormonotoxin, an LHRH Analog Conjugated to Dermaseptin-B2, a Multifunctional Antimicrobial Peptide

Prostate cancer is the most common cancer in men. For patients with advanced or metastatic prostate cancer, available treatments can slow down its progression but cannot cure it. The development of innovative drugs resulting from the exploration of…

Mickael Couty, Marie Dusaud, Mickael Miro-Padovani, Liuhui Zhang, Patricia Zadigue, Loussiné Zargarian, Olivier Lequin, Alexandre de la Taille, Jean Delbe, Yamina Hamma-Kourbali, Mohamed Amiche

International Journal of Molecular Sciences -

Chimie

Multimolecular complexes of the phosphodiester anion with Zn( II ) or Mg( II ) and water molecules—Preliminary validations of a polarizable potential by ab initio quantum chemistry

Dimethyl phosphate (DMP−) is a model for the phosphodiester backbone of DNA, RNA, and phospholipids. It is central for the binding of divalent cations and water along the backbone of nucleic acids. Significant polarization and charge-transfer…

Nohad Gresh, David Perahia

Journal of Computational Chemistry -

Sciences du Vivant

MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel

BACKGROUND: MicroRNAs (miRs) play critical roles in regulation of numerous biological events, including cardiac electrophysiology and arrhythmia, through a canonical RNA interference mechanism. It remains unknown whether endogenous miRs modulate…

Dandan Yang, Xiaoping Wan, Adrienne T Dennis, Emre Bektik, Zhihua Wang, Mauricio G S Costa, Charline Fagnen, Catherine Vénien-Bryan, Xianyao Xu, Daniel H Gratz, Thomas J Hund, Peter J Mohler, Kenneth R Laurita, Isabelle Deschênes, Ji-Dong Fu

Circulation -