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Publications

Affichage des publications 101 à 110 sur 136 au total

Sciences de l'environnement

Protein Kinase D1 (PKD1) Is a New Functional Non-Genomic Target of Bisphenol A in Breast Cancer Cells

Exposure to bisphenol A (BPA), one of the most widespread endocrine disruptors present in our environment, has been associated with the recent increased prevalence and severity of several diseases such as diabetes, obesity, autism, reproductive and…

Messaouda Merzoug-Larabi, Ilige Youssef, Ai Thu Bui, Christine Legay, Sophia Loiodice, Sophie Lognon, Sylvie Babajko, Jean-Marc Ricort

Frontiers in Pharmacology -

Pharmacologie

A Decrease in Transcription Capacity Limits Growth Rate upon Translation Inhibition

In bacterial cells, inhibition of ribosomes by sublethal concentrations of antibiotics leads to a decrease in the growth rate despite an increase in ribosome content. The limitation of ribosomal activity results in an increase in the level of…

Qing Zhang, Elisa Brambilla, Rui Li, Hualin Shi, Marco Cosentino Lagomarsino, Bianca Sclavi

mSystems -

Sciences du Vivant

A Toolbox for Site-Specific Labeling of RecQ Helicase With a Single Fluorophore Used in the Single-Molecule Assay

Fluorescently labeled proteins can improve the detection sensitivity and have been widely used in a variety of biological measurements. In single-molecule assays, site-specific labeling of proteins enables the visualization of molecular interactions…

Fang-Yuan Teng, Zong-Zhe Jiang, Ling-Yun Huang, Man Guo, Feng Chen, Xi-Miao Hou, Xu-Guang Xi, Yong Xu

Frontiers in Molecular Biosciences -

Sciences du Vivant

PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration

Corpus callosum agenesis (CCA) is a brain malformation associated with a wide clinical spectrum including intellectual disability (ID) and an etiopathological complexity. We identified a novel missense G424R mutation in the X-linked p21-activated…

Kévin Duarte, Solveig Heide, Sandrine Poea-Guyon, Veronique Rousseau, Christel Depienne, Agnès Rastetter, Caroline Nava, Tania Attié-Bitach, Ferechté Razavi, Jelena Martinovic, Marie Laure Moutard, Jacqueline Cherfils, Cyril Mignot, Delphine Héron, Jean-Vianney Barnier

Neurobiology of Disease -

Biochimie, Biologie Moléculaire

The N-terminal of NBPF15 causes multiple types of aggregates and mediates phase transition

The neuroblastoma breakpoint family (NBPF) consists of 24 members that play an important role in neuroblastoma and other cancers. NBPF is an evolutionarily recent gene family that encodes several repeats of Olduvai domain and an abundant N-terminal…

Han Wu, Liu-Tao Zhai, Xue-Xue Guo, Stéphane Réty, Xu-Guang Xi

Biochemical Journal -

Biotechnologies

Suitability of the Lebanese “Ace Spur” Apple Variety for Cider Production Using Hanseniaspora sp. Yeast

In the present research work, the physicochemical and fermentative properties of the “Ace spur” apple variety, obtained from a Lebanese farm, and the “Kermerrien” variety, obtained from a French cider industry, were investigated. The pomological…

Marina Al Daccache, Mohamed Koubaa, Richard G. Maroun, Dominique Salameh, Nicolas Louka, Eugene Vorobiev

Fermentation -

Biologie cellulaire

Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial

Objective: To assess masitinib in the treatment of ALS. Methods: Double-blind study, randomly assigning 394 patients (1:1:1) to receive riluzole (100 mg/d) plus placebo or masitinib at 4.5 or 3.0 mg/kg/d. Following a blinded transition from phase 2…

Jesus Mora, Angela Genge, Adriano Chiò, Conrado Estol, Delia Chaverri, Maria Hernández, Saúl Marín, Javier Mascias, Gabriel Rodríguez, Monica Povedano, Andrés Paipa, Raúl Dominguez, Josep Gámez, Maria Salvado, Christian Lunetta, Carlos Ballario, Nilo Riva, Jessica Mandrioli, Alain Moussy, Jean-Pierre Kinet, Christian Auclair, Patrice Dubreuil, Vincent Arnold, Colin Mansfield, Olivier Hermine

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration -

Biophysique

Harnessing intrinsic fluorescence for typing of secondary structures of DNA

High-throughput investigation of structural diversity of nucleic acids is hampered by the lack of suitable label-free methods, combining fast and cheap experimental workflow with high information content. Here, we explore the use of intrinsic…

Michela Zuffo, Aurélie Gandolfini, Brahim Heddi, Anton Granzhan

Nucleic Acids Research -