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Publications

Affichage des publications 111 à 120 sur 136 au total

Biologie structurale

Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex

G-quadruplexes (G4) are secondary structures of nucleic acids that can form in cells and have diverse biological functions. Several biologically important proteins interact with G-quadruplexes, of which RHAU - a helicase from the DEAH-box…

Brahim Heddi, Vee Vee Cheong, Emmanuelle Schmitt, Yves Mechulam, Anh Tuân Phan

Journal of Structural Biology -

Sciences du Vivant

DHX36-mediated G-quadruplex unfolding is ATP-independent?

Chen et al. solved the crystal structure of bovine DHX36 bound to a DNA with a G-quadruplex (G4) and a single-stranded DNA segment. They believed that the mechanism they proposed may represent a general model for describing how a G4-unfolding…

Hai-Lei Guo, Wei-Fei Chen, Stéphane Réty, Na-Nv Liu, Ze-Yu Song, Yan-Xue Dai, Xi-Miao Hou, Shuo-Xing Dou, Xu-Guang Xi

Biochimie, Biologie Moléculaire

Slow motions in A·T rich DNA sequence

In free B-DNA, slow (microsecond-to-millisecond) motions that involve equilibrium between Watson-Crick (WC) and Hoogsteen (HG) base-pairing expand the DNA dynamic repertoire that could mediate DNA-protein assemblies. R 1ρ relaxation dispersion NMR…

A Ben Imeddourene, L Zargarian, M Buckle, B Hartmann, Olivier Mauffret

Scientific Reports -

Sciences du Vivant

A Decrease in Transcription Capacity Limits Growth Rate upon Translation Inhibition

In bacterial cells, inhibition of ribosomes by sublethal concentrations of antibiotics leads to a decrease in the growth rate despite an increase in ribosome content. The limitation of ribosomal activity results in an increase in the level of…

Qing Zhang, Elisa Brambilla, Rui Li, Hualin Shi, Marco Cosentino Lagomarsino, Bianca Sclavi

mSystems -