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Publications

Affichage des publications 111 à 120 sur 148 au total

Chimie

Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1 H -pyrazole-5-carboxylate as an HIV-1 replication inhibitor

(ESI) available: . See Inspired by the antiviral activity of known pyrazole-based HIV inhibitors, we screened our in-house library of pyrazole-based compounds to evaluate their in cellulo activity against HIV-1 replication. Two hits with very…

Jeanne Fichez, Cathia Soulié, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier-Pelletier, Anne-Geneviève Marcelin, Vincent Calvez, Patricia Busca

RSC Medicinal Chemistry -

Biologie structurale

Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex

G-quadruplexes (G4) are secondary structures of nucleic acids that can form in cells and have diverse biological functions. Several biologically important proteins interact with G-quadruplexes, of which RHAU - a helicase from the DEAH-box…

Brahim Heddi, Vee Vee Cheong, Emmanuelle Schmitt, Yves Mechulam, Anh Tuân Phan

Journal of Structural Biology -

Bactériologie

Cytosolic Crowding Drives the Dynamics of Both Genome and Cytosol in Escherichia coli Challenged with Sub-lethal Antibiotic Treatments

In contrast to their molecular mode of action, the system-level effect of antibiotics on cells is only beginning to be quantified. Molecular crowding is expected to be a relevant global regulator, which we explore here through the dynamic response…

Michal Wlodarski, Leonardo Mancini, Bianca Raciti, Bianca Sclavi, Marco Cosentino Lagomarsino, Pietro Cicuta

iScience -

Agrégats Moléculaires et Atomiques

New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies

Inward rectifier potassium (Kir) channels play diverse and important roles in shaping action potentials in biological membranes. An increasing number of diseases are now known to be directly associated with abnormal Kir function. However, the gating…

Charline Fagnen, Ludovic Bannwarth, Iman Oubella, Eric Forest, Rita de Zorzi, Aline de Araujo, Yasmina Mhoumadi, Saïd Bendahhou, David Perahia, Catherine Vénien-Bryan

Scientific Reports -

Alimentation et Nutrition

Selective ultrasound‐assisted aqueous extraction of polyphenols from pomegranate peels and seeds

In this study, the optimization of ultrasound‐assisted aqueous extraction of polyphenols from pomegranate peels and seeds was conducted. A 10‐min sonication (tu ) pre‐treatment (≈60 W) accelerated the extraction kinetics and intensified the…

Hiba Rajha, Mohamed Koubaa, Nadia Boussetta, Richard G. Maroun, Nicolas Louka, Nikolaï Lebovka, Eugene Vorobiev

Journal of Food Processing and Preservation -

Biochimie, Biologie Moléculaire

Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States

HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the…

Assia Mouhand, Marco Pasi, Marjorie Catala, Loussiné Zargarian, Anissa Belfetmi, Pierre Barraud, Olivier Mauffret, Carine Tisné

Viruses -

Santé publique et épidémiologie

A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome

Bahia Bekhouche, Aurore Tourville, Yamini Ravichandran, Rachida Tacine, Laurence Abrami, Michaël Dussiot, Andrea Khau-Dancasius, Olivia Boccara, Meriem Khirat, Marianne Mangeney, Florent Dingli, Damarys Loew, Batiste Boëda, Pénélope Jordan, Thierry Jo Molina, Nathalia Bellon, Sylvie Fraitag, Smaïl Hadj-Rabia, Stephane Blanche, Anne Puel, Sandrine Etienne-Manneville, F Gisou van Der Goot, Jacqueline Cherfils, Olivier Hermine, Jean-Laurent Casanova, Christine Bodemer, Asma Smahi, Jérôme Delon

Journal of Allergy and Clinical Immunology -