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Publications

Affichage des publications 111 à 120 sur 139 au total

Bactériologie

Cytosolic Crowding Drives the Dynamics of Both Genome and Cytosol in Escherichia coli Challenged with Sub-lethal Antibiotic Treatments

In contrast to their molecular mode of action, the system-level effect of antibiotics on cells is only beginning to be quantified. Molecular crowding is expected to be a relevant global regulator, which we explore here through the dynamic response…

Michal Wlodarski, Leonardo Mancini, Bianca Raciti, Bianca Sclavi, Marco Cosentino Lagomarsino, Pietro Cicuta

iScience -

Agrégats Moléculaires et Atomiques

New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies

Inward rectifier potassium (Kir) channels play diverse and important roles in shaping action potentials in biological membranes. An increasing number of diseases are now known to be directly associated with abnormal Kir function. However, the gating…

Charline Fagnen, Ludovic Bannwarth, Iman Oubella, Eric Forest, Rita de Zorzi, Aline de Araujo, Yasmina Mhoumadi, Saïd Bendahhou, David Perahia, Catherine Vénien-Bryan

Scientific Reports -

Alimentation et Nutrition

Selective ultrasound‐assisted aqueous extraction of polyphenols from pomegranate peels and seeds

In this study, the optimization of ultrasound‐assisted aqueous extraction of polyphenols from pomegranate peels and seeds was conducted. A 10‐min sonication (tu ) pre‐treatment (≈60 W) accelerated the extraction kinetics and intensified the…

Hiba Rajha, Mohamed Koubaa, Nadia Boussetta, Richard G. Maroun, Nicolas Louka, Nikolaï Lebovka, Eugene Vorobiev

Journal of Food Processing and Preservation -

Sciences du Vivant

DHX36-mediated G-quadruplex unfolding is ATP-independent?

Chen et al. solved the crystal structure of bovine DHX36 bound to a DNA with a G-quadruplex (G4) and a single-stranded DNA segment. They believed that the mechanism they proposed may represent a general model for describing how a G4-unfolding…

Hai-Lei Guo, Wei-Fei Chen, Stéphane Réty, Na-Nv Liu, Ze-Yu Song, Yan-Xue Dai, Xi-Miao Hou, Shuo-Xing Dou, Xu-Guang Xi

Biochimie, Biologie Moléculaire

Slow motions in A·T rich DNA sequence

In free B-DNA, slow (microsecond-to-millisecond) motions that involve equilibrium between Watson-Crick (WC) and Hoogsteen (HG) base-pairing expand the DNA dynamic repertoire that could mediate DNA-protein assemblies. R 1ρ relaxation dispersion NMR…

A Ben Imeddourene, L Zargarian, M Buckle, B Hartmann, Olivier Mauffret

Scientific Reports -

Sciences du Vivant

A Decrease in Transcription Capacity Limits Growth Rate upon Translation Inhibition

In bacterial cells, inhibition of ribosomes by sublethal concentrations of antibiotics leads to a decrease in the growth rate despite an increase in ribosome content. The limitation of ribosomal activity results in an increase in the level of…

Qing Zhang, Elisa Brambilla, Rui Li, Hualin Shi, Marco Cosentino Lagomarsino, Bianca Sclavi

mSystems -