Publications

Biologie structurale

Structural study of the function of Candida Albicans Pif1

Pif1 helicases, conserved in eukaryotes, are involved in maintaining genome stability in both the nucleus and mitochondria. Here, we report the crystal structure of a truncated Candida Albicans Pif1 (CaP-if1 368À883) in complex with ssDNA and an ATP…

Ke-Yu Lu, Ben-Ge Xin, Teng Zhang, Na-Nv Liu, Dan Li, Stephane Rety, Xu-Guang Xi

Biochemical and Biophysical Research Communications - 2021

Bactériologie

Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition

Pif1 is an SF1B helicase that is evolutionarily conserved from bacteria to humans and plays multiple roles in maintaining genome stability in both nucleus and mitochondria. Though highly conserved, Pif1 family harbors a large mechanistic diversity…

Yang-Xue Dai, Wei-Fei Chen, Na-Nv Liu, Fang-Yuan Teng, Hai-Lei Guo, Xi-Miao Hou, Shuo-Xing Dou, Stephane Rety, Xu-Guang Xi

Nucleic Acids Research - 2021

Sciences de l'ingénieur

Model reduction techniques for quantitative nano-mechanical AFM mode

Xuyang Chang, Stéphane Roux, Simon Hallais, Kostas Danas

Measurement Science and Technology - 2021

Biochimie, Biologie Moléculaire

The allosteric activation mechanism of a phospholipase A2-like toxin from Bothrops jararacussu venom: a dynamic description

Abstract The activation process of phospholipase A 2 -like (PLA 2 -like) toxins is a key step in their molecular mechanism, which involves oligomeric changes leading to the exposure of specific sites. Few studies have focused on the characterization…

Antoniel Gomes, Fabio Cardoso, Maximilia Souza, Cristiano Oliveira, David Perahia, Angelo Magro, Marcos Fontes

Scientific Reports - 2020

Chimie

Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1 H -pyrazole-5-carboxylate as an HIV-1 replication inhibitor

Inspired by the antiviral activity of known pyrazole-based HIV inhibitors, we screened our in-house library of pyrazole-based compounds to evaluate their in cellulo activity against HIV-1 replication. Two hits with very similar structures appeared…

Jeanne Fichez, Cathia Soulie, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier-Pelletier, Anne-Geneviève Marcelin, Vincent Calvez, Patricia Busca

RSC Medicinal Chemistry - 2020

Sciences du Vivant

Differences Between Europe and the United States on AI/Digital Policy: Comment Response to Roundtable Discussion on AI

For AI policy, there are significant differences between Europe and the United States. The General Data Protection Regulation, which applies not only to European Union companies but also to all American companies with European customers, is more…

Pierre-Antoine Gourraud, Francoise Simon

Gender and the Genome - 2020

Bio-Informatique, Biologie Systémique

A New Strategy for Atomic Flexible Fitting in Cryo-EM Maps by Molecular Dynamics with Excited Normal Modes (MDeNM-EMfit)

Previous studies demonstrated the efficiency of the Molecular Dynamics with excited Normal Modes (MDeNM) method on the characterization of large structural changes at a low computational cost. We present here MDeNM-EMfit, an extension of the…

Mauricio G S Costa, Charline Fagnen, Catherine Vénien-Bryan, David Perahia

Journal of Chemical Information and Modeling - 2020

Biophysique

Gold nanorods-based oligonucleotides carrier quantitative characterisation

Gold nanorods (GNRs) are attracting a lot of attention due to their extraordinary optical properties, and potential use for medical applications. The issue of the attachment of double stranded oligonucleotides onto GNR surfaces is crucial for the…

Henryk Laszewski, Bruno Palpant, Malcolm Buckle, Claude Nogues

2020 International Conference Laser Optics (ICLO) - 2020

Bactériologie

Cytosolic Crowding Drives the Dynamics of Both Genome and Cytosol in Escherichia coli Challenged with Sub-lethal Antibiotic Treatments

In contrast to their molecular mode of action, the system-level effect of antibiotics on cells is only beginning to be quantified. Molecular crowding is expected to be a relevant global regulator, which we explore here through the dynamic response…

Michal Wlodarski, Leonardo Mancini, Bianca Raciti, Bianca Sclavi, Marco Cosentino Lagomarsino, Pietro Cicuta

iScience - 2020

Agrégats Moléculaires et Atomiques

New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies

Inward rectifier potassium (Kir) channels play diverse and important roles in shaping action potentials in biological membranes. An increasing number of diseases are now known to be directly associated with abnormal Kir function. However, the gating…

Charline Fagnen, Ludovic Bannwarth, Iman Oubella, Eric Forest, Rita de Zorzi, Aline de Araujo, Yasmina Mhoumadi, Saïd Bendahhou, David Perahia, Catherine Vénien-Bryan

Scientific Reports - 2020