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Publications

Affichage des publications 91 à 100 sur 139 au total

Sciences du Vivant

Human RPA activates BLM’s bidirectional DNA unwinding from a nick

BLM is a multifunctional helicase that plays critical roles in maintaining genome stability. It processes distinct DNA substrates, but not nicked DNA, during many steps in DNA replication and repair. However, how BLM prepares itself for diverse…

Zhenheng Qin, Lulu Bi, Xi-Miao Hou, Siqi Zhang, Xia Zhang, Ying Lu, Ming Li, Mauro Modesti, Xu-Guang Xi, Bo Sun

eLife -

Polymères

Fluorescent Copolymers for Bacterial Bioimaging and Viability Detection

Novel fluorescent labels with high photostability and high biocompatibility are required for microbiological imaging and detection. Here, we present a green fluorescent polymer chain (GFPC), designed to be nontoxic and water-soluble, for multicolor…

Yang Si, Chloé Grazon, Gilles Clavier, Jutta Rieger, Yayang Tian, Jean-Frédéric Audibert, Bianca Sclavi, Rachel Méallet-Renault

ACS Sensors -

Virologie

SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends

Understanding the viral-host cell interface during HIV-1 infection is a prerequisite for the development of innovative antiviral therapies. Here we show that the suppressor of G2 allele of skp1 (SUGT1) is a permissive factor for human…

Awatef Allouch, Cristina Di Primio, Audrey Paoletti, Gabrielle Lê-Bury, Frédéric Subra, Valentina Quercioli, Roberta Nardacci, Annie David, Héla Saidi, Anna Cereseto, David M. Ojcius, Guillaume Montagnac, Florence Niedergang, Gianfranco Pancino, Asier Sáez-Cirión, Mauro Piacentini, Marie-Lise Gougeon, Guido Kroemer, Jean-Luc Perfettini

Cell Death and Differentiation -

Sciences du Vivant

Design of Light-Sensitive Triggers for Endothelial NO-Synthase Activation

A specific light trigger for activating endothelial Nitric Oxide-Synthase (eNOS) in real time would be of unique value to decipher cellular events associated with eNOS activation or to generate on demand cytotoxic levels of NO at specific sites for…

Sébastien Dilly, Linda J Roman, Nicolas Bogliotti, Juan Xie, Éric Deprez, Anny Slama-Schwok

Antioxidants -

Biologie végétale

Impact of pulsed electric fields and mechanical compressions on the permeability and structure of Chlamydomonas reinhardtii cells

Current research findings clearly reveal the role of the microalga's cell wall as a key obstacle to an efficient and optimal compound extraction. Such extraction process is therefore closely related to the microalga species used. Effects of…

Sakina Bensalem, Dominique Pareau, Bertrand Cinquin, Olivier Français, Bruno Le Pioufle, Filipa Lopes

Scientific Reports -

Chimie

Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1 H -pyrazole-5-carboxylate as an HIV-1 replication inhibitor

(ESI) available: . See Inspired by the antiviral activity of known pyrazole-based HIV inhibitors, we screened our in-house library of pyrazole-based compounds to evaluate their in cellulo activity against HIV-1 replication. Two hits with very…

Jeanne Fichez, Cathia Soulié, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier-Pelletier, Anne-Geneviève Marcelin, Vincent Calvez, Patricia Busca

RSC Medicinal Chemistry -

Biologie structurale

Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex

G-quadruplexes (G4) are secondary structures of nucleic acids that can form in cells and have diverse biological functions. Several biologically important proteins interact with G-quadruplexes, of which RHAU - a helicase from the DEAH-box…

Brahim Heddi, Vee Vee Cheong, Emmanuelle Schmitt, Yves Mechulam, Anh Tuân Phan

Journal of Structural Biology -