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Publications

Affichage des publications 91 à 100 sur 159 au total

Biophysique

Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

There is increasing support for water molecules playing a role in signal propagation through G protein-coupled receptors (GPCRs). However, exploration of the hydration features of GPCRs is still in its infancy. Here, we combined site-specific…

Maxime Louet, Marina Casiraghi, Marjorie Damian, Mauricio Gs Costa, Pedro Renault, Antoniel As Gomes, Paulo R Batista, Céline M'Kadmi, Sophie Mary, Sonia Cantel, Severine Denoyelle, Khoubaib Ben Haj Salah, David Perahia, Paulo M Bisch, Jean-Alain Fehrentz, Laurent J Catoire, Nicolas Floquet, Jean-Louis Banères

eLife -

Biochimie, Biologie Moléculaire

Modulation of cellular fate of vinyl triarylamines through structural fine tuning: to stay or not to stay in the mitochondria?

Mitochondria is involved in many cellular pathways and dysfunctional mitochondria are linked to various diseases. Hence efforts have been driven to design mitochondria-targeted fluorophores for monitoring the mitochondria status. However, the…

Laura Fourmois, Florent Poyer, Aude Sourdon, Delphine Naud-Martin, Sounderya Nagarajan, Rahima Chennoufi, Eric Deprez, Marie-Paule Teulade-Fichou, Florence Mahuteau-Betzer

ChemBioChem -

Biologie structurale

Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi

Telomerase plays critical roles in cellular aging, in the emergence and/or development of cancer, and in the capacity for stem-cell renewal, consists of a catalytic telomerase reverse transcriptase (TERT) and a template-encoding RNA (TER). TERs from…

Liu-Tao Zhai, Stephane Rety, Wei-Fei Chen, Ze-Yu Song, Daniel Auguin, Bo Sun, Shuo-Xing Dou, Xu-Guang Xi

Nucleic Acids Research -

Biologie structurale

Unexpected Gating Behaviour of an Engineered Potassium Channel Kir

In this study, we investigated the dynamics and functional characteristics of the KirBac3.1 S129R, a mutated bacterial potassium channel for which the inner pore-lining helix (TM2) was engineered so that the bundle crossing is trapped in an open…

Charline Fagnen, Ludovic Bannwarth, Dania Zuniga, Iman Oubella, Rita de Zorzi, Eric Forest, Rosa Scala, Samuel Guilbault, Saïd Bendahhou, David Perahia, Catherine Vénien-Bryan

Frontiers in Molecular Biosciences -

Biologie structurale

Structural study of the function of Candida Albicans Pif1

Pif1 helicases, conserved in eukaryotes, are involved in maintaining genome stability in both the nucleus and mitochondria. Here, we report the crystal structure of a truncated Candida Albicans Pif1 (CaP-if1 368À883) in complex with ssDNA and an ATP…

Ke-Yu Lu, Ben-Ge Xin, Teng Zhang, Na-Nv Liu, Dan Li, Stephane Rety, Xu-Guang Xi

Biochemical and Biophysical Research Communications -

Bactériologie

Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition

Pif1 is an SF1B helicase that is evolutionarily conserved from bacteria to humans and plays multiple roles in maintaining genome stability in both nucleus and mitochondria. Though highly conserved, Pif1 family harbors a large mechanistic diversity…

Yang-Xue Dai, Wei-Fei Chen, Na-Nv Liu, Fang-Yuan Teng, Hai-Lei Guo, Xi-Miao Hou, Shuo-Xing Dou, Stephane Rety, Xu-Guang Xi

Nucleic Acids Research -

Urologie et Néphrologie

Antitumor Activity and Mechanism of Action of Hormonotoxin, an LHRH Analog Conjugated to Dermaseptin-B2, a Multifunctional Antimicrobial Peptide

Prostate cancer is the most common cancer in men. For patients with advanced or metastatic prostate cancer, available treatments can slow down its progression but cannot cure it. The development of innovative drugs resulting from the exploration of…

Mickael Couty, Marie Dusaud, Micka Miro-Padovani, Liuhui Zhan, Patricia Zadigue, Loussiné Zargarian, Olivier Lequin, Alexandre de La Taille, Jean Delbe, Yamina Hamma-Kourbali, Mohamed Amiche

International Journal of Molecular Sciences -