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Publications

Affichage des publications 91 à 100 sur 173 au total

Chimie

Multimolecular complexes of the phosphodiester anion with Zn( II ) or Mg( II ) and water molecules—Preliminary validations of a polarizable potential by ab initio quantum chemistry

Dimethyl phosphate (DMP−) is a model for the phosphodiester backbone of DNA, RNA, and phospholipids. It is central for the binding of divalent cations and water along the backbone of nucleic acids. Significant polarization and charge-transfer…

Nohad Gresh, David Perahia

Journal of Computational Chemistry -

Sciences du Vivant

MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel

BACKGROUND: MicroRNAs (miRs) play critical roles in regulation of numerous biological events, including cardiac electrophysiology and arrhythmia, through a canonical RNA interference mechanism. It remains unknown whether endogenous miRs modulate…

Dandan Yang, Xiaoping Wan, Adrienne T Dennis, Emre Bektik, Zhihua Wang, Mauricio G S Costa, Charline Fagnen, Catherine Vénien-Bryan, Xianyao Xu, Daniel H Gratz, Thomas J Hund, Peter J Mohler, Kenneth R Laurita, Isabelle Deschênes, Ji-Dong Fu

Circulation -

Biophysique

Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

There is increasing support for water molecules playing a role in signal propagation through G protein-coupled receptors (GPCRs). However, exploration of the hydration features of GPCRs is still in its infancy. Here, we combined site-specific…

Maxime Louet, Marina Casiraghi, Marjorie Damian, Mauricio Gs Costa, Pedro Renault, Antoniel As Gomes, Paulo R Batista, Céline M'Kadmi, Sophie Mary, Sonia Cantel, Severine Denoyelle, Khoubaib Ben Haj Salah, David Perahia, Paulo M Bisch, Jean-Alain Fehrentz, Laurent J Catoire, Nicolas Floquet, Jean-Louis Banères

eLife -

Biochimie, Biologie Moléculaire

Modulation of cellular fate of vinyl triarylamines through structural fine tuning: to stay or not to stay in the mitochondria?

Mitochondria is involved in many cellular pathways and dysfunctional mitochondria are linked to various diseases. Hence efforts have been driven to design mitochondria-targeted fluorophores for monitoring the mitochondria status. However, the…

Laura Fourmois, Florent Poyer, Aude Sourdon, Delphine Naud-Martin, Sounderya Nagarajan, Rahima Chennoufi, Eric Deprez, Marie-Paule Teulade-Fichou, Florence Mahuteau-Betzer

ChemBioChem -

Biologie structurale

Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi

Telomerase plays critical roles in cellular aging, in the emergence and/or development of cancer, and in the capacity for stem-cell renewal, consists of a catalytic telomerase reverse transcriptase (TERT) and a template-encoding RNA (TER). TERs from…

Liu-Tao Zhai, Stephane Rety, Wei-Fei Chen, Ze-Yu Song, Daniel Auguin, Bo Sun, Shuo-Xing Dou, Xu-Guang Xi

Nucleic Acids Research -

Biologie structurale

Unexpected Gating Behaviour of an Engineered Potassium Channel Kir

In this study, we investigated the dynamics and functional characteristics of the KirBac3.1 S129R, a mutated bacterial potassium channel for which the inner pore-lining helix (TM2) was engineered so that the bundle crossing is trapped in an open…

Charline Fagnen, Ludovic Bannwarth, Dania Zuniga, Iman Oubella, Rita de Zorzi, Eric Forest, Rosa Scala, Samuel Guilbault, Saïd Bendahhou, David Perahia, Catherine Vénien-Bryan

Frontiers in Molecular Biosciences -