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Showing posts 91 to 100 of 173 total

Chimie

Multimolecular complexes of the phosphodiester anion with Zn( II ) or Mg( II ) and water molecules—Preliminary validations of a polarizable potential by ab initio quantum chemistry

Dimethyl phosphate (DMP−) is a model for the phosphodiester backbone of DNA, RNA, and phospholipids. It is central for the binding of divalent cations and water along the backbone of nucleic acids. Significant polarization and charge-transfer…

Nohad Gresh, David Perahia

Journal of Computational Chemistry -

Sciences du Vivant

MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel

BACKGROUND: MicroRNAs (miRs) play critical roles in regulation of numerous biological events, including cardiac electrophysiology and arrhythmia, through a canonical RNA interference mechanism. It remains unknown whether endogenous miRs modulate…

Dandan Yang, Xiaoping Wan, Adrienne T Dennis, Emre Bektik, Zhihua Wang, Mauricio G S Costa, Charline Fagnen, Catherine Vénien-Bryan, Xianyao Xu, Daniel H Gratz, Thomas J Hund, Peter J Mohler, Kenneth R Laurita, Isabelle Deschênes, Ji-Dong Fu

Circulation -

Mécanique des fluides

Out-of-Equilibrium Measurements of Kinetic Constants on a Biosensor

Conventional measurements of kinetic constants currently in use are performed at equilibrium and may require large volumes, especially at low association rate constant k on. If the measurements are made out of equilibrium, the values obtained may be…

Donatien Mottin, Florence Razan, Claude Nogues, Marie-Caroline Jullien

Analytical Chemistry -

Biochimie

Endogenous Bos taurus RECQL is predominantly monomeric and more active than oligomers

There is broad consensus that RecQ family helicase is a high-order oligomer that dissociates into a dimer upon ATP binding. This conclusion is based mainly on studies of highly purified recombinant proteins, and the oligomeric states of RecQ…

Na-Nv Liu, Ze-Yu Song, Hai-Lei Guo, Hu Yin, Wei-Fei Chen, Yang-Xue Dai, Ben-Ge Xin, Xia Ai, Lei Ji, Qing-Man Wang, Xi-Miao Hou, Shuo-Xing Dou, Stephane Rety, Xu-Guang Xi

Cell Reports -

Bactériologie

Threshold accumulation of a constitutive protein explains E. coli cell-division behavior in nutrient upshifts

Despite a boost of recent progress in dynamic single-cell measurements and analyses in Escherichia coli , we still lack a mechanistic understanding of the determinants of the decision to divide. Specifically, the debate is open regarding the…

Mia Panlilio, Jacopo Grilli, Giorgio Tallarico, Ilaria Iuliani, Bianca Sclavi, Pietro Cicuta, Marco Cosentino Lagomarsino

Proceedings of the National Academy of Sciences of the United States of America -

Biologie structurale

Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition

Pif1 is an SF1B helicase that is evolutionarily conserved from bacteria to humans and plays multiple roles in maintaining genome stability in both nucleus and mitochondria. Though highly conserved, Pif1 family harbors a large mechanistic diversity…

Yang-Xue Dai, Wei-Fei Chen, Na-Nv Liu, Fang-Yuan Teng, Hai-Lei Guo, Xi-Miao Hou, Shuo-Xing Dou, Stephane Rety, Xu-Guang Xi

Nucleic Acids Research -