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Sciences du Vivant

The convergence of head-on DNA unwinding forks induces helicase oligomerization and activity transition

Helicases are multifunctional motor proteins with the primary task of separating nucleic acid duplexes. These enzymes often exist in distinct oligomeric forms and play essential roles during nucleic acid metabolism. Whether there is a correlation…

Lulu Bi, Zhenheng Qin, Teng Wang, Yanan Li, Xinshuo Jia, Xia Zhang, Xi-Miao Hou, Mauro Modesti, Xu-Guang Xi, Bo Sun

Proceedings of the National Academy of Sciences of the United States of America -

Biophysique

Synthesis and Spectroscopic Characterization of Novel Thiourea-Bearing Photoactivatable NADPH Mimics Targeting NO Synthases

Abstract A new set of photoactivatable NADPH mimics bearing a thiourea linkage between a diarylbutadiene and an adenosine moiety functionalized by O-carboxymethyl groups has been designed and synthesized in a convergent strategy. These compounds…

Clément Polese, Eric Deprez, Patrick Tauc, Nicolas Bogliotti, Juan Xie

Synthesis: Journal of Synthetic Organic Chemistry -

Sciences du Vivant

Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration

Integration of the reverse-transcribed genome is a critical step of the retroviral life cycle. Strand-transfer inhibitors (INSTIs) used for antiretroviral therapy inhibit integration but can lead to resistance mutations in the integrase gene, the…

Clémence Richetta, Frédéric Subra, Isabelle Malet, Hervé Leh, Charlotte Charpentier, Angela Corona, Gilles Collin, Diane Descamps, Eric Deprez, Vincent Parissi, Vincent Calvez, Enzo Tramontano, Anne-Geneviève Marcelin, Olivier Delelis

Journal of Virology -

Maladies émergentes

Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent that has caused the current coronavirus disease (COVID) pandemic. Viral infection relies on the viral S (spike) protein/cellular receptor ACE2 interaction…

Delphine Lapaillerie, Cathy Charlier, Véronique Guyonnet-Dupérat, Emilie Murigneux, Henrique S Fernandes, Fábio G Martins, Rita P Magalhães, Tatiana F Vieira, Clémence Richetta, Frédéric Subra, Samuel Lebourgeois, Charlotte Charpentier, Diane Descamps, Benoît Visseaux, Pierre Weigel, Alexandre Favereaux, Claire Beauvineau, Frédéric Buron, Marie-Paule Teulade-Fichou, Sylvain Routier, Sarah Gallois-Montbrun, Laurent Meertens, Olivier Delelis, Sérgio F Sousa, Vincent Parissi

Antimicrobial Agents and Chemotherapy -

Virologie

Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent that has caused the current coronavirus disease (COVID) pandemic. Viral infection relies on the viral S (spike) protein/cellular receptor ACE2 interaction.

Delphine Lapaillerie, Cathy Charlier, Véronique Guyonnet-Dupérat, Emilie Murigneux, Henrique Fernandes, Fábio Martins, Rita Magalhães, Tatiana Vieira, Clémence Richetta, Frédéric Subra, Samuel Lebourgeois, Charlotte Charpentier, Diane Descamps, Benoît Visseaux, Pierre Weigel, Alexandre Favereaux, Claire Beauvineau, Frédéric Buron, Marie-Paule Teulade-Fichou, Sylvain Routier, Sarah Gallois-Montbrun, Laurent Meertens, Olivier Delelis, Sérgio Sousa, Vincent Parissi

Antimicrobial Agents and Chemotherapy -

Virologie

Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration

Our work highlights the role of HIV-1 unintegrated viral DNA in viral replication. A virus, resistant to strand-transfer inhibitors, has been selected in vitro . This virus highlights a mutation in the 3'PPT region and not in the integrase gene…

Clémence Richetta, Frédéric Subra, Isabelle Malet, Hervé Leh, Charlotte Charpentier, Angela Corona, Gilles Collin, Diane Descamps, Eric Deprez, Vincent Parissi, Vincent Calvez, Enzo Tramontano, Anne-Geneviève Marcelin, Olivier Delelis

Journal of Virology -

Sciences du Vivant

Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates

Bloom syndrome protein (BLM) is a conserved RecQ family helicase involved in the maintenance of genome stability. BLM has been widely recognized as a genome "caretaker" that processes structured DNA. In contrast, our knowledge of how BLM behaves on…

Teng Wang, Jiaojiao Hu, Yanan Li, Lulu Bi, Lijuan Guo, Xinshuo Jia, Xia Zhang, Dan Li, Xi‐miao Hou, Mauro Modesti, Xu‐guang Xi, Cong Liu, Bo Sun

Angewandte Chemie International Edition -

Sciences du Vivant

Systemic inflammatory syndrome in children with FARSA deficiency

Variants in aminoacyl-tRNA synthetases (ARSs) genes are associated to a broad spectrum of human inherited diseases. Patients with defective PheRS, encoded by FARSA and FARSB, display brain abnormalities, interstitial lung disease and facial dys-…

Fabienne Charbit-Henrion, Roman Goguyer-Deschaumes, Keren Borensztajn, Marc Mirande, Jérémy Berthelet, Fernando Rodrigues-Lima, Anis Khiat, Marie‐louise Frémond, Brigitte Bader-Meunier, Marco Rodari, Luis Seabra, Gillian Rice, Marie Legendre, David Drummond, Laureline Berteloot, Charles‐joris Roux, Nathalie Boddaert, Philippe Drabent, Thierry Jo Molina, Florence Lacaille, Manoelle Kossorotoff, Nadine Cerf-Bensussan, Marianna Parlato, Alice Hadchouel

Clinical Genetics -

Bactériologie

Structural mechanism underpinning Thermus oshimai Pif1‐mediated G‐quadruplex unfolding

G-quadruplexes (G4s) are unusual stable DNA structures that cause genomic instability. To overcome the potential barriers formed by G4s, cells have evolved different families of proteins that unfold G4s. Pif1 is a DNA helicase from superfamily 1 …

Yang‐Xue Dai, Hai‐Lei Guo, Na‐Nv Liu, Wei‐Fei Chen, Xia Ai, Hai‐Hong Li, Bo Sun, Xi‐Miao Hou, Stephane Rety, Xu‐Guang Xi

EMBO Reports -

Chimie

FRET-mediated quenching of BODIPY fluorescent nanoparticles by methylene blue and its application to bacterial imaging

High resolution and good signal to noise ratio is a requirement in cell imaging. However, after labelling with fluorescent entities, and besides several washing steps, there is often an unwanted fluorescent background that reduces the images…

Yang Si, Chloé Grazon, Gilles Clavier, Jean-Frédéric Audibert, Bianca Sclavi, Rachel Meallet-Renault

Photochemical & Photobiological Sciences -