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Publications

Affichage des publications 141 à 150 sur 173 au total

Virologie

SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends

Understanding the viral-host cell interface during HIV-1 infection is a prerequisite for the development of innovative antiviral therapies. Here we show that the suppressor of G2 allele of skp1 (SUGT1) is a permissive factor for human…

Awatef Allouch, Cristina Di Primio, Audrey Paoletti, Gabrielle Lê-Bury, Frédéric Subra, Valentina Quercioli, Roberta Nardacci, Annie David, Héla Saidi, Anna Cereseto, David M. Ojcius, Guillaume Montagnac, Florence Niedergang, Gianfranco Pancino, Asier Sáez-Cirión, Mauro Piacentini, Marie-Lise Gougeon, Guido Kroemer, Jean-Luc Perfettini

Cell Death and Differentiation -

Sciences du Vivant

Design of Light-Sensitive Triggers for Endothelial NO-Synthase Activation

A specific light trigger for activating endothelial Nitric Oxide-Synthase (eNOS) in real time would be of unique value to decipher cellular events associated with eNOS activation or to generate on demand cytotoxic levels of NO at specific sites for…

Sébastien Dilly, Linda J Roman, Nicolas Bogliotti, Juan Xie, Éric Deprez, Anny Slama-Schwok

Antioxidants -

Biologie végétale

Impact of pulsed electric fields and mechanical compressions on the permeability and structure of Chlamydomonas reinhardtii cells

Current research findings clearly reveal the role of the microalga's cell wall as a key obstacle to an efficient and optimal compound extraction. Such extraction process is therefore closely related to the microalga species used. Effects of…

Sakina Bensalem, Dominique Pareau, Bertrand Cinquin, Olivier Français, Bruno Le Pioufle, Filipa Lopes

Scientific Reports -

Chimie

Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1 H -pyrazole-5-carboxylate as an HIV-1 replication inhibitor

(ESI) available: . See Inspired by the antiviral activity of known pyrazole-based HIV inhibitors, we screened our in-house library of pyrazole-based compounds to evaluate their in cellulo activity against HIV-1 replication. Two hits with very…

Jeanne Fichez, Cathia Soulié, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier-Pelletier, Anne-Geneviève Marcelin, Vincent Calvez, Patricia Busca

RSC Medicinal Chemistry -

Biologie structurale

Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex

G-quadruplexes (G4) are secondary structures of nucleic acids that can form in cells and have diverse biological functions. Several biologically important proteins interact with G-quadruplexes, of which RHAU - a helicase from the DEAH-box…

Brahim Heddi, Vee Vee Cheong, Emmanuelle Schmitt, Yves Mechulam, Anh Tuân Phan

Journal of Structural Biology -

Sciences du Vivant

DHX36-mediated G-quadruplex unfolding is ATP-independent?

Chen et al. solved the crystal structure of bovine DHX36 bound to a DNA with a G-quadruplex (G4) and a single-stranded DNA segment. They believed that the mechanism they proposed may represent a general model for describing how a G4-unfolding…

Hai-Lei Guo, Wei-Fei Chen, Stéphane Réty, Na-Nv Liu, Ze-Yu Song, Yan-Xue Dai, Xi-Miao Hou, Shuo-Xing Dou, Xu-Guang Xi

Biochimie, Biologie Moléculaire

Slow motions in A·T rich DNA sequence

In free B-DNA, slow (microsecond-to-millisecond) motions that involve equilibrium between Watson-Crick (WC) and Hoogsteen (HG) base-pairing expand the DNA dynamic repertoire that could mediate DNA-protein assemblies. R 1ρ relaxation dispersion NMR…

A Ben Imeddourene, L Zargarian, M Buckle, B Hartmann, Olivier Mauffret

Scientific Reports -