IMPA
Membrane Interfaces and Associated Diseases
Composition de l'équipe:
- Agata Nawrotek (PI, team leader CRCN CNRS)
- Mahel Zeghouf (PI, researcher CRCN CNRS)
- Yann Ferrandez (researcher, ENS Paris-Saclay)
- Gerald Peyroche (Professor, ENS Paris-Saclay)
- Marie-Hélène Kryszke (Associate Professor, ENS Paris-Saclay)
- Franck Gesbert (Associate Professor U Paris-Saclay, chercheur associé)
- Cyril Pages (PhD)
- Wajed Shah (PhD)
- Ambre Jacquet (PhD)
We pay particular attention to the molecular mechanisms at play, especially the reciprocal regulations between proteins and membranes, and their implications in the context of disease. Our work is positioned within the early stages of therapeutic development, contributing to the early drug discovery process.
To achieve our research goals, we adopt a multidisciplinary approach that includes protein biochemistry, the design of biomimetic systems on artificial membranes, cell biology, advanced imaging (including TIRF and confocal microscopy), fluorescence spectroscopy, and integrated structural biology, encompassing X-ray crystallography and cryo-electron microscopy.
Our projects revolve around two main research axes, defined by the proteins BCR and IQSEC - key molecular players involved in essential cellular processes, as well as in cancer and neurodevelopmental disorders.
Axes Thématiques
