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ENS Cachan - Laboratoire de biologie et de pharmacologie appliquée (LBPA)

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Research - Commercialisation

Recent publications (2011-2016)

Olivier Mauffret Team


Belfetmi A., Zargarian L., Tisné C., Sleiman D., Morellet N., Lescop E., Maskri O., René B, Mély Y., Fossé P., Mauffret O. (2016) Insights into the mechanisms of RNA secondary structure destabilization by the HIV-1 nucleocapsid protein. RNA, in press.

Ben Imeddourene A, Xu X, Zargarian L, Oguey C, Foloppe N, Mauffret O, Hartmann B. (2016) The intrinsic mechanics of B-DNA in solution characterized by NMR. Nucleic Acids Res., in press.

Chen Y., Maskri O., Chaminade F., René B., Benkaroun J., Godet J., Mély Y., Mauffret O., Fossé P. (2016) Structural insights into the HIV-1 minus-strand strong-stop DNA. J Biol Chem, in press.

Wei-Fei Chen, Yang-Xue Dai, Xiao-Lei Duan, Na-Nv Liu, Wei Shi, Na Li, Ming Li, Shou-Xing Dou, Yu-Hui Dong, Stephane Rety and Xu-Guang Xi. (2016) Crystal structures of the BsPif1 helicase reveal that a major movement of the 2B SH3 domain is required for DNA unwinding. Nucleic Acids Research, 2016, in press.


Ben Imeddourene A, Elbahnsi A, Guéroult M, Oguey C, Foloppe N, Hartmann B. (2015) Simulations Meet Experiment to Reveal New Insights into DNA Intrinsic Mechanics. PLoS Comput Biol. 11(12):e1004631.

Liu NN, Duan XL, Ai X, Yang YT, Li M, Dou SX, Rety S, Deprez E, Xi XG. (2015) The Bacteroides sp. 3_1_23 Pif1 protein is a multifunctional helicase. Nucleic Acids Res. 43(18):8942-54.

Wu WQ, Hou XM, Li M, Dou SX, Xi XG. (2015) BLM unfolds G-quadruplexes in different structural environments through different mechanisms. Nucleic Acids Res. 43(9):4614-26.

Wang S, Qin W, Li JH, Lu Y, Lu KY, Nong DG, Dou SX, Xu CH, Xi XG, Li M. (2015) Unwinding forward and sliding back: an intermittent unwinding mode of the BLM helicase. Nucleic Acids Res. 43(7):3736-46.

Duan XL, Liu NN, Yang YT, Li HH, Li M, Dou SX, Xi XG. (2015) G-quadruplexes significantly stimulate Pif1 helicase-catalyzed duplex DNA unwinding. J Biol Chem. 290(12):7722-35.

Hou XM, Wu WQ, Duan XL, Liu NN, Li HH, Fu J, Dou SX, Li M, Xi XG. (2015) Molecular mechanism of G-quadruplex unwinding helicase: sequential and repetitive unfolding of G-quadruplex by Pif1 helicase. Biochem J. 466(1):189-99

Elbahnsi A, Mauffret O, Perahia D, Hartmann B, Oguey C. (2015) 25 New insights on nucleic acids - protein interfaces revealed by VLDM, a geometrical approach. J Biomol Struct Dyn. 33 Suppl 1:14-5.

Nodin L, Noël O, Chaminade F, Maskri O, Barbier V, David O, Fossé P, Xie J. (2015) RNA SHAPE chemistry with aromatic acylating reagents. Bioorg Med Chem Lett. 25(3):566-70.


Qin W, Liu NN, Wang L, Zhou M, Ren H, Bugnard E, Liu JL, Zhang LH, Vendôme J, Hu JS, Xi XG. (2014) Characterization of biochemical properties of Bacillus subtilis RecQ helicase. Bacteriol. 196(24):4216-28.

Xu X, Ben Imeddourene A, Zargarian L, Foloppe N, Mauffret O, Hartmann B. (2014) NMR studies of DNA support the role of pre-existing minor groove variations in nucleosome indirect readout. Biochemistry. 53(35):5601-12.

Zargarian L, Tisné C, Barraud P, Xu X, Morellet N, René B, Mély Y, Fossé P, Mauffret O. (2014) Dynamics of linker residues modulate the nucleic acid binding properties of the HIV-1 nucleocapsid protein zinc fingers. PLoS One. 9(7):e102150.

Darlix JL, de Rocquigny H, Mauffret O, Mély Y. (2014) Retrospective on the all-in-one retroviral nucleocapsid protein. Virus Res. 193:2-15.

Boudier C, Humbert N, Chaminade F, Chen Y, de Rocquigny H, Godet J, Mauffret O, Fossé P, Mély Y. (2014) Dynamic interactions of the HIV-1 Tat with nucleic acids are critical for Tat activity in reverse transcription. Nucleic Acids Res. 42(2):1065-78.


Devineau S, Zanotti JM, Loupiac C, Zargarian L, Neiers F, Pin S, Renault JP. (2013) Myoglobin on silica: a case study of the impact of adsorption on protein structure and dynamics. Langmuir. 29(44):13465-72.

Li W, Hou XM, Wang PY, Xi XG, Li M. (2013) Direct measurement of sequential folding pathway and energy landscape of human telomeric G-quadruplex structures. J Am Chem Soc. 135(17):6423-6.

Foloppe N., Guéroult M., Hartmann B. (2013) Simulating DNA by molecular dynamics: aims, methods and validation. Methods Mol Biol. 924: 445-68.

Bazzi, A., Zargarian, L., Chaminade, F., De Rocquigny, H., René, B., Mély, Y., Fossé, P. & Mauffret, O. (2012) Intrinsic nucleic acids dynamics modulates HIV-1 nucleocapsid protein binding to its targets. PLoS ONE , 7(6):e41704

Xu Y.N., Bazeille N., Ding X.Y., Lu X.M., Wang P.Y., Bugnard E., Grondin V.,  Dou S.X., Xi X.G. (2012) Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structures. Nucleic Acids Res. 40(19):9802-14.

Guéroult M., Boittin O., Mauffret O., Etchebest E., Hartmann B. (2012) Mg2+ in the major groove modulates B-DNA structure and dynamics. PLoS ONE 2012 7(7):e41704.

Bazzi A., Zargarian L., Chaminade F., Boudier C., De Rocquigny H., René B., Mély Y., Fossé P., and Mauffret O. (2011) Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC. Nucleic Acids Res., 39(9):3903-3916.

Kaushik, S., Kaushik, M., Svinarchuk, F., Malvy, M., Fermandjian, S., & Kukrekti, S. (2011) Presence of divalent cation is not mandatory for the formation of intramolecular Purine-Motif Triplex containing human-cjun protooncogene target., Biochemistry, 50(19):4132-4142.

Darlix, JL., Godet, J., Ivanyi-Nagy, R., Fossé, P., Mauffret, O. & Mély, Y. (2011) Flexible nature and specific functions of the HIV-1 nucleocapsid protein. J.Mol.Biol., 410(4):565-581.

Kanevsky, I., Chaminade, F., Chen, YY., Godet, J., René, B., Darlix, JL., Mély, Y., Mauffret, O., Fossé, P. (2011) Structural determinants of TAR DNA annealing in the absence and presence of HIV-1 nucleocapsid protein. Nucleic Acids Res., 39(18):8148-62.

KJ. M. Zaal1, E.Reid, K. Mousavi, T. Zhang, A. Mehta, E. Bugnard, V. Sartorelli, E. Ralston (2011) Who Needs Microtubules? Myogenic Reorganization of MTOC, Golgi Complex and ER Exit Sites Persists Despite Lack of Normal Microtubule Tracks. PLoS ONE, 6 (12), e29057.

Wang Y, Xiao H, Wu N, Shi H, Xu H, Zhou L, Xi XG, Wang T, Wang X.(2011) Characterization of the antiviral activity for influenza viruses M1 zinc finger peptides. Curr Microbiol.62(1):126-32.