Direct access to content

ENS Cachan - Laboratoire de biologie et de pharmacologie appliquée (LBPA)

French version


Home > Teams > Small GTPases

Cherfils lab - Follow us

Merci de nous rendre visite! Thank you for visiting us!

WELCOME! Livia Tepshi joined the lab in May 2018.

Livia obtained her PhD in 2017 at the CEA in Saclay, where she worked on a retrograde transport inhibitor .

CONFERENCE! François Peurois gave a talk at the Young Researchers in Life Sciences Conference in Paris (May 4th 2018).


Jacqueline's profile is on SBGrid Member Tales !

WELCOME! Ellyn Renou joined our lab in April 2018

Ellyn est ingénieure diplômée de l'Université de Technologie de Compiègne (UTC), promotion 2017 en Génie Biologique filière Conception et Innovation de Bioproduits. Bienvenue!


ENS PARIS-SACLAY! Our future building (March 2018)!

GOODBYE! Ilham Ladhid has found a new position at the Institut Curie starting in April 2018.

From left to right: Noelia, Gérald, Jacqueline, Mahel, Lurlène, François, Ilham, Simon, Yann, Christian. Wenhua and Marie-Hélène are missing from the photo.

BIOPHYSICS WEEK! We participated in this event organized by the Universidad Complutense de Madrid and high school students from Aranjuez on "Women in Science, Women in Biophysics" (12-16 March 2018).

CONFERENCE! Mahel Zeghouf and François Peurois gave talks at "From Molecules and Cells to Human Health: ideas and concepts", 5-9 Mars 2018, IHES Bures-sur-Yvette

NEW PUBLICATION! Our review on "FIC proteins: from bacteria to human and back again" by Veyron S., Peyroche G. and Cherfils J. is now live in free access on the website of Pathogens and Disease

BIOPHYSICS! Jacqueline gave a talk at the Symposium on Biophysics of lipid-modified GTPases at the 62nd meeting of the Biophysical Society in San Francisco (Feb 2018).

Two positions are open immediately:
Assistant ingénieur in molecular biology and recombinant protein production
Post-doc in integrated structural biology of small GTPases
Both positions are funded by the Institut National du Cancer until December 2018 and can be renewed. Contacts us at to learn more.

BIOPHYSICS! The European Biophysical Societies' Association (EBSA) executive committee met in January 2018.

The meeting took place at the Istituto Veneto di Scienze Lettere ed Arti in Venice. A painting by Tintoretto (1518-1594) in the meeting room!

CONFERENCE! Christian Galicia gave a talk at the 13th SOLEIL Users' Meeting (Januanry 2018)


SPECIAL EVENT! Gérald Peyroche was a member of a French delegation from the Université Paris-Saclay, Pasteur Institute and Pasteur Institute of Cambodia  invited by the University of Health Sciences in Cambodia (Novembre 2017).

CONFERENCE! We were at the 5th meeting of the LABEX LERMIT (15 December 2017)

Mahel Zeghouf co-organized the meeting and François Peurois gave a talk.

THESIS DEFENSE! Congratulations Simon! (11 December 2017)

Many thanks to the thesis committee for a great discussion! From left to right: Dr Isabelle Broutin (Université Paris-Descartes, Paris), Prof. Pedro Alzari (Pasteur Institute, Paris), Dr Yves Mechulam (Ecole Polytechnique, Palaiseau), Dr Jean-Michel Jault (IBCP, Lyon), Prof. Herman van Tilbeurgh (Université Paris-Saclay, Orsay).

NEW PUBLICATION! Our preview on "Allosteric regulation of mTOR signaling: the structure of the Rag GTPase/Ragulator complex" is now live on the website of Molecular Cell (7 Dec 2017). 

SEMINAR! Wenhua Zhang gave a seminar at the Lanzhou University - School of Life Sciences on Dec 1st 2017

INTERSHIP! Julien Majou did his ENS L3 internship in November 2017 in our lab

Julien learning the art of liposome-making with his supervisor François Peurois

NEW PUBLICATION! Our article by Yann Ferrandez, Wenhua Zhang et al. on "Allosteric inhibition of the guanine nucleoide exchange factor Dock5 by a small molecule" is now live on the website of Scientific Reports (31 Oct 2017)

Wenhua and Yann collecting SAXS data at SOLEIL

MID-THESIS EXAM! François Peurois passed his mid-thesis exam (PhD qualifying exam) on 20 October 2017. Congratulations!

François with committee member Dr Frédérique Gaits-Iacovoni, INSERM Toulouse

COMMENTARY ON OUR ARTICLE! A commentary by John Hancock on our article, entitled "Lipid sorting and the activity of Arf signaling complexes", has been published in PNAS!

ART OF SCIENCE! A stamp to celebrate our article in PNAS!
It is a long-standing tradition in John Kuriyan's lab that the first authors design a stamp about their work and their country. This one is Agata's with the crowned Polish eagle. 

CONFERENCE!  Jorge Navaza was at the Conference on methods and applications in the frontier between MX and Cryo-EM in Barcelona 17-21 September 2017.

The Nobel prize in Chemistry 2017 was awarded on October 4th to Jacques Dubochet, Joachim Franck and Richard Henderson for developing cryo-electron microscopy for the high resolution structure determination of biomolecules in solution. A fantastic day for structural biology! Blow up the picture to see Jorge and a future Nobel prize laureate!

ON THE WEB! 3 Octobre 2017. On parle de nous sur le site de l'Institut National des Sciences Biologiques du CNRS et sur le site du Département Life Sciences de l'Université Paris Saclay!

NEW PUBLICATION ! Our article by Karandur D., Nawrotek A. et al. on "Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane" is now live on the website of PNAS.

CONFERENCE! 10-15 september 2017.
Mahel gave a talk at the EMBO meeting on "Endocytic trafficking and signaling in health and disease" in Serock, Polland.

SPORT IN SCIENCE! 10 Septembre 2017. Jacqueline a couru La Parisienne avec la Fondation pour la Recherche Médicale!

IN THE NEWS! 9 September 2017. Una leonesa en la élite de la cristalografía.

Noelia Bernardo Garcia is in the Diario de León (recognize the snap?)

NEW PUBLICATION!  Our article by Benabdi S, Peurois F. et al. on "Family-wide analysis of the inhibition of Arf guanine nucleotide exchange factors by small molecules : evidence for unique inhibitory profiles" is now live on the website of Biochemistry

CONFERENCE! We organized the "Protein structure to function" session at the EBSA/IUPAB congress in Edinburgh (16-20 July) 

From left to right: Malcolm Walkinshaw (University of Edinburgh, session co-chair), Tamir Gonen (HHMI, invited speaker), Yu-Chih Lo (Taiwan), André Hoelz (CalTech, invited speaker), Tea Pavkov-Keller (University of Graz, Austria).

CONGRATULATION! Gérald Peyroche a été promu Maître de Conférences
de Classe Exceptionelle de l'ENS Paris-Saclay! Bravo!

CONFERENCE! 26-30 June 2017.
Jacqueline gave a talk and Simon presented a poster at ETOX18 in Paris.

CONFERENCE! 19-23 June 2017.
Jacqueline gave a talk and Simon Veyron presented a poster at the Gordon Research Conference on Proteins in Holderness, NH, co-organized by Cathy Royer.

CONFERENCE! 12-16 June 2017. Jacqueline gave a talk at the FASEB conference on Regulation and Function of Small GTPases in West Palm Beach, Florida, which was organized by Angeliki Kalliri and Carol Williams.

The best conference ending ever! Can you figure out the tune?

WORKSHOP! 22-23 Juin 2017. Mahel Zeghouf organized a workshop on "Spectroscopie de fluorescence: principes et application à l'étude des protéines"

Plus d'information sur le site de CNRS Formation Entreprises

SEMINAR! 7 June 2017. Jacqueline gave a talk on inhibitors of small GTPases at PIRAMID Scientific day in Nantes.

The scientific network PIRAMID studies Protein Interactions in Rational Approaches for Medicinal Innovatove Drugs.

THEY'RE VISITING OUR LAB! We were delighted to host Dr Jeff Martell, from the Miller Institute in Berkeley, and Monica Neugebauer (University of California, Berkeley). Jeff gave a beautiful talk on his work on engineered heme peroxidases as genetically encoded probes with diverse applications in cell biology (19th May 2017)

Jeff and Monica (center) met with post-docs and students. From left to right: Wenhua, Yann, Simon, Christian, Agata, Rudolf, Jahnavi and François.

NEW PUBLICATION! Our article by Blackburn et al. on"How to name atoms in polyphosphates, their derivatives and mimics, and transition state analogues for enzyme-catalysed phosphoryl transfer reaction (IUPAC Recommendations 2016)
is now live in open access on the web site of Pure and Applied Chemistry.

Meet the authors! Mike Blackburn toasting glasses with Jacqueline

CONFERENCE! François Peurois gave a talk at the Young Researchers in Life Sciences.

WELCOME! May 2017. Tessa Dehau joined our lab for an undergraduate internship.

Tessa est en 4ème année d'école d'ingénieur à l'INSA Lyon, filière Biochimie & Biotechnologies du département Biosciences.

NEW PUBLICATION! Our article by Wesolowski et al. on "Chlamydia hijacks Arf GTPases to coordinate Microtubule posttranslational modification and Golgi Complex positioning", in collaboration with the laboratory of Fabienne Paumet at Thomas Jefferson Unversity, Philadelphia, is now live on the web site of MBio.

WELCOME! April 2017. Noelia Bernardo García joined our lab.

Noelia did her PhD in the Department of Crystallography and Structural Biology, Instituto de Química Física Rocasolano (CSIC) in Madrid.

OUR FUTURE CAMPUS! April 2017. The construction of our future Campus has started!

More about the project by Renzo Piano HERE

NEW PUBLICATION! Our article on  "Identification of cancer-associated missense mutations in Hace1 that impair cell growth control and Rac1 ubiquitylation" in collaboration with the laboratory of Emmanuel Lemichez (INSERM, NICE) The article is live on in open access on the web site of Scientific Reports

NEW PUBLICATION! Our article "Characterization of the activation of small GTPases by their GEFs using artificial membrane tethering" by Peurois et al. 
is live on the web site of the Biochemical Journal

WELCOME! February 2017. Jahnavi and Rudolf joined our lab for a Master internship.

Jahnavi Cheekireddy obtained a M.Sc in Pharmaceutical Sciences at  the Vellore Institute of Technology (VIT University), Vellore, India. She is a laureate of the International Program of the Ecole Normale Supérieure Paris-Saclay. Rudolf Hergesheimer obtained a M.Sc. in Molecular and Cellular Biology at the University of California, Santa Barbara (UCSB). He has been awarded an Advanced Student grant by the Fulbright Franco-American Program.

CONFERENCE! January 20, 2017. Agata Nawrotek gave a talk at the 12th SOLEIL Users' Meeting.

GOOD MEMORIES! Le Livre d'Or  du LEBS / The goldbook of LEBS
Livre Or LEBS

Le Livre d'Or (goldbook) du Laboratoire d'Enzymologie garde le souvenir des collègues et amis qui ont donné un séminaire au Laboratoire d'Enzymologie de 1975 à 2014. Agrandissez l'image pour voir si votre nom y figure / Blow up the photo to see if you were there!

Visit our posts 2015 HERE
Visit our posts 2014 HERE.